复方丹参注射液治疗急性脑梗死的疗效及其作用机理探讨.pdf

维普资讯

中国由酉医结台杂志2002年5月第22卷第5期

复方丹参注射液治疗急性脑梗死的疗效

及其作用机理探讨

闭连秋党立颖马维艳袁静

内容提要目的：从氧自由基和载脂蛋白角度探讨复方丹参注射液治疗急性脑梗死的疗效及机理。方

法：68例发病在1周以内的脑梗死患者，随机分为复方丹参研究组(简称研究组，34例)和血栓通对照组(简

称对照组，34例)进行临床观察。应用比邑法洲定血清脂质过氧化物(LPO)和超氧化物歧化酶(SOD)，单向

免疫法测定载脂蛋白A1(APOA~)和载脂蛋白B100(ApoBl00)。结果：复方丹参注射液能使患者血清的LPO、

ApoB瑚水平明显降低，同时显著升高血清的SOD、APOA1水平，且与对照组治疗后比较，差异有显著性(P

0．05或P0．O1)；治疗组的总有效率为88．24％，明显高于对照组(P0．05)。结论：复方丹参注射液治疗

脑梗死疗效确切，抗脂质过氧化损伤和调节载脂蛋白代谢可能是其重要的作用机理。

关键词复方丹参注射液脑梗死氧自由基载脂蛋白

ClinicalStudyonEffectandTherapeuticalMechanismofCompositeSalvialnjectiononAcuteCerebralInfarc-

tJonMINIAan—qiu，DANGLi—ying，MAwel_yan，etalDepartmentofNeurology，theFirstAliatedHospi

ta1．JinzhouMedicalCollege，Liaoning(121001)

objective：ToinvestigatethecurativeeffectandtherapeuticaJmechanismofcompositesalviainjection

(CSI)intreatingischemiccerebralinfarctionintherespectofoxygenfreeradicalandapolipopmtein．Methods：

Sixty—eightcasesofischemiccerebra1infarctionwithinthefirst72hrsafteronsetweredividedrandomlyintothe

CS1group(treatedwithCSI)andthecontrolgroup(treatedwithxueshuant0ng)．Serumlipidperoxide(LP())

andsuperoxidedismutase(OSD)weremeasuredbycolorimetryandapolipoproteinA】(ApoAt)andApoB100

weremeasuredwithunidirectiona1ilnmunediffusionmethodResults：Serum1evelsofLP0andApoB，00were

obviouslylower，andlevelsofSODandApoA1significantlyhigherintheCSIgroupthanthoseinthecontrol

group(P0．05orP0．01)Tl1etotaleffectiverateofCSIintreatingcerebra1infarctionvcas88．24％．

whichwassignificantlyhigherthanthatofthecontro1(P0．05)Conclusion：CSIshowsdefiniteeffectin

treatingcerebralinfarction，toreducetheoxygenfreeradicaldamageandregulatetheapolipoproteinmetabolism

possiblywastheimportanttherapeutica1mechanism

Keywordscompositesalviainjection，cerebra1infarction，oxygenfreeradical，a