LSD1-IN-32-生命科学试剂-MCE.pdf

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LSD1-IN-32

Cat.No.:HY-161869

分⼦式:C₃₆H₅₆N₂O₃Si₂

分⼦量:621.01

作⽤靶点:HistoneMethyltransferase

作⽤通路:Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性LSD1-IN-32(compound11e)是⼀种有效的LSD1抑制剂，其IC50值为0.99µM。LSD1-IN-32可抑制RANKL

诱导的破⾻细胞⽣成、⾻吸收和F-肌动蛋⽩带形成。LSD1-IN-32具有研究⾻质疏松症的潜⼒[1]。

IC50TargetIC50:0.99µM(LSD1)[1]

体外研究LSD1-IN-32(compound11e)(1.25,2.5,5µM)increasesthemethylationlevelduringosteoclastogenesisina

dose-dependentmanner[1].

LSD1-IN-32(0.25,0.5,1,2,4µM)inhibitsRANKL-inducedosteoclastogenesis,boneresorptionandF-actin

beltformation[1].

LSD1-IN-32(2µM;0,1,2,4days)reducestherelativemRNAexpressionlevelsinducedbyRANKLofthose

genesofAcp5,Nfatc1,Oscar,Dc-stamp,Atp6v0d2,andCtsk[1].

LSD1-IN-32(0.5,1,2,4µM)inhibitstheexpressionsofp-LSD1,p-IκBandp-NFκBinRANKL-induced

osteoclastogenesis[1].

RT-PCR[1]

CellLine:osteoclasts

Concentration:2µM

IncubationTime:0,1,