LX7101-monohydrochloride-生命科学试剂-MCE.pdf

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LX7101monohydrochloride

Cat.No.:HY-12659B

CASNo.:2319882-48-7

分⼦式:C₂₃H₃₀ClN₇O₃

分⼦量:487.98

作⽤靶点:LIMKinase(LIMK);ROCK;PKA

作⽤通路:CellCycle/DNADamage;Cytoskeleton;StemCell/Wnt;TGF-

beta/Smad

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性LX7101monohydrochloride是⼀种有效的双重LIM激酶和ROCK抑制剂，对LIMK1、LIMK2、ROCK2和PKA

的IC50分别为24nM、1.6nM、10nM和50值分别为4.3nM和32nM。LX7101monohydrochloride具有

⽤于眼⾼压和相关青光眼研究的潜⼒。

IC50TargetLIMK1LIMK2ROCK2PKA

24nM(IC50)1.6nM(IC50)10nM(IC50)50)

体内研究LX7101(200μg/40μLeyedrop)monohydrochloridedisplaysasignificantintraocularpressure(IOP)

reductionattimepointsrangingfrom1hto6hpostadministrationinocularnormotensiveNewZealand

White(NZW)rabbits[1].

客户使⽤本产品发表的科研⽂献

•Oncogene.2023Mar16.

•SciRep.2018Aug2;8(1):11585.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].BolandS,etal.Design,synthesisandbiologicalcharacterizationofselectiveLIMKinhibitors.BioorganicMedicinalChemist