Macrophage-activating-lipopeptide-2-MALP-2-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Macrophage-activatinglipopeptide2

Cat.No.:HY-P10586

CASNo.:250718-44-6

Synonyms:MALP-2

分⼦式:C₉₉H₁₆₇N₁₉O₃₀S

分⼦量:2135.56

Sequence:{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-Gly-Asn-Asn

-Asp-Glu-Ser-Asn-Ile-Ser-Phe-Lys-Glu-Lys

SequenceShortening:{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-

GNNDESNISFKEK

作⽤靶点:Toll-likeReceptor(TLR)

作⽤通路:Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Macrophage-activatinglipopeptide2(MALP-2)是⼀种脂肽Toll样受体TLR-2/6激动剂。Macrophage-

activatinglipopeptide2(MALP-2)可以增强⽩细胞的内⽪粘附，可以改善接受实验性股动脉结扎(FAL)的⾼胆

固醇⾎症Apoe缺陷⼩⿏后肢的灌注恢复和侧⽀⽣长。

体外研究Macrophage-activatinglipopeptide2(MALP-2)(1µg/mL,24h)canpromotetheexpressionofmajor

endothelialadhesionmoleculesandleukocyteintegrinreceptors,therebyenhancingleukocyteendothelial

adhesion[1].

RT-PCR[1].

CellLine:EndothelialMyEndcells

Concentration:1µg/mL

IncubationTime:24h

Result:CausedastrongtransientincreaseinmRNAlevelsofvascularcelladhesi