药学专业英语视听说教程 课件 视听说上篇lecture 5 Pharmaceutics.pptx

Lecture5Pharmaceutics

bioavailabilitylysosomeconjugatepartitioncoefficientaerodynamicsantibodydrugconjugate(抗体药物偶联物)

permeabilityexcipientformulationparenteralheterogeneous

finishedpharmaceuticalproductphysiologicalfunctionsactivepharmaceuticalingredientbiologicsinactivebiologicalsystems

formulationsimplantssensitivitypackaging

FFFFTTT

1.Whatarethepossibleroutesforenteraladministration?2.Whatarethepossibleroutesforparenteraladministration?

3.Whatisfirst-passeffect?Medicationsaremetabolizedbeforegainingtheirentrytickettothesystemiccirculation.

4.Whatisbioavailability?Itisameasureofabsorptionandreferstotheportionofamedicationthatreachesthesystemiccirculationwhenadministeredbynon-intravenousroutes.

5.Whatfactorsshouldbetakenintoaccountwhendecidingtherouteofadministration?----Thechemicalpropertiesofthemedicationitself,suchasitsstabilityanditsabilitytocrosscertainbarriersofabsorption.----First-passeffectandbioavailability.Drugswithextensivefirst-passmetabolismshouldn’tbeadministeredperorallyasitwoulddecreasetheirefficacy.----Anotherfactoristheurgencyofthesituation.Peroralmedicationsproduceaneffectmuchslowerthanintravenousonesandthusthelatterispreferredinemergencysettingsandduringsurgicalprocedures.

Howdobrainandanyotherorganinhumanbodygetoxygenandnutrients?----heartpumpsoxygenatedbloodintoarteries;----arteriesbranchoutintotinierandtinierbloodvesselscalledcapillaries;----capillariesdistributeintovarioustissues;----thethinwallsofcapillariesallowdiffusionofsubstancesacrossit.

WhatarethespecialstructurefeaturesthatmakeBBBhaveselectivepermeability?

WhatarethefunctionsoftransportersontheendotheliumofBBB?Theyletdifferentnutrientsinandwasteproductsout.

1.Whatinspiredthespeakertopursuetreatingbraindiseaseswithnewtherapeutics?Thetypicalexp