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Guidelineson
thediagnosisandmanagement
ofacutepulmonaryembolism——ESC上海德达医院
Classesofmendations
Levelsofevidence
PredisposingfactorsPredisposingfactorsforvenousthromboembolism:Table3
NaturalhistoryTheriskofVTEaftersurgeryishighestduringthefirst2weeksaftersurgerybutremainselevatedfor2–3months.AntithromboticprophylaxissignificantlyreducestheriskofperioperativeVTE.Thelongerthedurationofantithromboticprophylaxis,thelowertheincidenceofVTE.
MostpatientswithsymptomaticDVThaveproximalclots,andin40–50%ofcasesthisconditioniscomplicatedbyPE,oftenwithoutclinicalmanifestations.AsymptomaticPEiscommoninthepostoperativephase,particularlyinpatientswithasymptomaticDVTwhoarenotgivenanythromboprophylaxisPEoccurs3–7daysaftertheonsetofDVT
shockorhypotensionin5–10%ofcases,andinupto50%ofcaseswithoutshockbutwithlaboratorysignsofrightventriculardysfunction(RVD)and/orinjury,whichindicatesapoorerprognosis.completeresolution;two-thirdsofallpatientswithoutanticoagulation,about50%,within3monthsanticoagulationtreatmentatleast3-12monthsofanticoagulationtreatment
PathophysiologyTheconsequencesofacutePEareprimarilyhaemodynamicandeapparentwhen30–50%ofthepulmonaryarterialbedisoccludedbythromboemboli.Largeand/ormultipleembolimightabruptlyincreasepulmonaryvascularresistancetoalevelofafterloadwhichcannotbematchedbytherightventricle(RV).Suddendeath:Electormechanicaldissociationsyncopeand/orsystemichypotension
PathophysiologyPatientssurviving:activatethesympatheticsystemrestingpulmonaryflow,leftventricularfillingandoutput,Togetherwithsystemicvasoconstriction,RVcoronaryperfusionandthefunctionoftheRVSecondaryhaemodynamicdestabilizationmayoccur,usuallywithin?rst24–48h,re
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