塞克硝唑片治疗细菌性阴道病的临床分析.docx

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塞克硝唑片治疗细菌性阴道病的临床分析

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何先红

【摘要】目的评价塞克硝唑片治疗细菌性阴道病的有效性和安全性。方法256例细菌性阴道病患者随机分成对照组126例和试验组130例，分别给予甲硝唑片和塞克硝唑片口服；停药后3~5d及停药后下次月经来潮干净后3~7d比较两组的临床疗效，比较两组3个月内的复发率；并观察两组的不良反应的发生情况。结果停药后3~5d，对照组的治愈率和有效率分别为64.3%和82.5%，试验组的治愈率和有效率分别为76.2%和91.5%；停药后下次月经来潮干净后3~7d对照组的治愈率和有效率分别为65.9%和83.3%，试验组的治愈率和有效率分别为78.5%和92.3%;两组比较有显著性差异（P0.05）。两组间的不良反应发生率无显著性差异。结论塞克硝唑片治疗细菌性阴道病安全有效。

【关键词】

塞克硝唑；甲硝唑；细菌性阴道病

Clinicalevaluationofsecnidazoletabletintreatmentofbacterialvaginosis

HEXian-hong.DepartmentofObstetricandGynecology,ZixingMunicipalHospital,Hunan423400,China

【Abstract】ObjectiveToevaluatetheefficacyandsafetyofsecnidazoletabletintreatmentofbacterialvaginosis.Methods256patientswithbacterialvaginosiswererandomlydividedintocontrolgroup(n=126)andtrialgroup(n=130).Controlgroupweregivenmetronidazoletabletsandtrialgroupweregivensecnidazoletablets.Theclinicalefficacywascomparedbetweentwogroups3~7daysaftertheendoftreatmentand3~7daysaftermenorrhea,respectively.Therelapserateduring3monthsaftertheendoftreatmentbetweentwogroupswascompared.Thesideeffectsintwogroupswereobserved.Results3~7daysaftertheendoftreatment,thecurerateandefficacyratewere64.3%and82.5%incontrolgroupand76.2%and91.5%intrialgroup,respectively.3~7daysaftermenorrhea，thecurerateandefficacyratewere65.9%and83.3%incontrolgroupand78.5%and92.3%intrialgroup,respectively.Therewasasignificantdifferencebetweentwogroups.Therelapseratewas12.0%incontrolgroupand14.7%intrialgroup（P0.05）.Theincidenceofsideeffectsbetweentwogroupswasnotsignificantlydifferent.ConclusionSecnidazoletabletisefectiveandsafeinthetreatmentofbacterialvaginosis.

【Keywords】Seenidazole;Metronidazole;Bacterialvaginosis

细菌性阴道病(bacterialvaginosis,BV)是育龄期妇女最常见的阴道感染性疾病之一，约占外阴、阴道感染的40%~50%［1］，且近年来发病率有不断上升趋势。细菌性阴道病与盆腔炎、子宫内膜炎、不育、流产及早产等有着直接联系［2-3］，影响广大妇女的心身健康。因此，及时有效地治疗细菌性阴道病具有十分重要的意义。本研究拟评价塞克