甘草泻心汤加味治疗放化疗后口腔溃疡的系统评价-1.docxVIP

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甘草泻心汤加味治疗放化疗后口腔溃疡的系统评价

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贺忠宁王宝泉张培彤

摘要目的：系统评价甘草泻心汤加味治疗放化疗后口腔溃疡的疗效。方法：全面检索国家知识基础设施数据库（CNKI）、PubMed等8个中英文数据库，收集甘草泻心汤加味治疗放化疗后口腔溃疡的随机对照试验学术论文，从建库至2020年9月为各数据库的检索时限，选取2位评价员筛查挑选文献、数据提取、评价偏倚风险后，应用RevMan5.3对研究数据进行Meta分析。結果：初步检索到476篇文献，剔除重复及不符合纳入标准的文献后，最终纳入8个RCT，包括553例患者，观察组279例，对照组274例。甘草泻心汤加味治疗放化疗后口腔溃疡的总有效率（RR1.29，95%CI为1.19～1.40，P

关键词甘草泻心汤;放疗;化疗;癌症;口腔溃疡;观察组;对照组;系统评价

SystematicReviewofModifiedGancaoXiexinDecoctionintheTreatmentofOralUlcerafterRadiotherapyandChemotherapy

HEZhongning1，2，WANGBaoquan1，2，ZHANGPeitong2

（1BeijingUniversityofChineseMedicine，Beijing100029，China;2Guang′anmenHospital，ChinaAcademyofChineseMedicalScience，Beijing100053，China）

AbstractObjective：TosystematicallyevaluatetheeffectsofmodifedGancaoXiexinDecoctiononoralulcerafterradiotherapyandchemotherapy.Methods：Acomprehensivesearchof8ChineseandEnglishdatabasessuchastheNationalKnowledgeInfrastructureDatabase（CNKI）andPubMed，andthecollectionofrandomizedcontrolledtrialsacademicpapersonthetreatmentoforalulcersafterradiotherapyandchemotherapywithGancaoXiexinDecoction，fromtheestablishmentofthedatabasetoSeptember2020wereretrieved.476paperswereinitiallyretrieved.Afterexcludingduplicatesanddocumentsthatdidnotmeettheinclusioncriteria，8RCTswerefinallyincluded，including553patients，279casesinthetestgroup，and274casesinthecontrolgroup.2reviewerswereselectedforscreeningandselection.Afterliteratureselection，dataextraction，andevaluationoftheriskofbias，RevMan5.3wasusedtoconductameta-analysisoftheresearchdata.Results：ThetotaleffectiverateofmodifedGancaoXiexinDecoctioninthetreatmentofradiationandchemotherapyinpatientswithoralulcers（RR1.29，95%CI1.19to1.40，P

KeywordsGancaoXiexinDecoction;Radiotherapy;Chemotherapy;Cancer;Mouthulcers;Testgroup;Controlgroup;Systemevaluation

：R289.5：Adoi：10.3969/j.issn.1673-7202.2021.09.013

口腔溃