生物可降解明胶微球的制备及体外降解.pdfVIP

DOI:10.13413/j.cnki.jdxblxb.2008.01.023

461()Vo.l46No.1

20081JOURNALOFJILINUNIVERSITY(SCIENCEEDITION)Jan2008

1231111

,,,,,,

(1.,130021;2.,475001;

3.,130018)

:以生物可降解明胶为载体,采用乳化交联法制备明胶微球,考察了固化剂加入时间

微球质量的影响,并通过正交实验研究了明胶溶液的浓度、搅拌速度、水油相比例微球粒

径的影响.结果表明,所制备的明胶微球,具有粒径均一、成球率高的特点,微球表面平滑,

平均粒径为13.72μm.

:明胶;微球;乳化交联法;固化剂;正交设计

:R944.9:A:1671-5489(2008)01-0143-05

PrearationandIn-vitroDegradationofBiodegradable

GelatinMicrosheres

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JIANGDan,TANGZhao-jun,JIANGYun-lei,LIUCheng-bai,WANGFei,

11

LINXiang-you,CHENXia

(1.CollegeofLifeScience,JilinUniversity,Changchun130021,China;

2.LabofSecialFunctionMaterial,sHenanUniversity,Kaifeng475001,HenanProvinc,eChina;

3.CollegeofAnmialTechnology,JilinAgriculturalUniversity,Changchun130018,China)

Abstrac:tGelatinmicroshereswererearedbymeansofemulsionchemical-crosslinetechnique.Inorderto

gainthebesthomogeneoussizeandarameter,sitwasdemonstratedthatsolidifyingreagentaddingtmiehad

effectsongelatinmicroshere.sTherearationconditionsofthemicrosheressuchasgelatinconcentration,

agitaterate,ratioofwatertooilhasewerestudiedanddiscussed.Thesurfacemorhologyandthesizeofthe

microshereswereobservedbySEM.Theresultshowsthatthemicrosheresrearedhaverelativelyuniform

diamete,rtheaveragediameterinthisstudyis13.72μm,andthesurfaceofthemicrosheresis