多索茶碱与布地奈德联合应用于支气管哮喘治疗的疗效与安全性观察.docxVIP

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多索茶碱与布地奈德联合应用于支气管哮喘治疗的疗效与安全性观察

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【摘要】目的分析多索茶碱与布地奈德联合应用在支气管哮喘治疗中的应用效果和安全性。方法收集2017年6月至2019年5月我院收治的70例支气管哮喘患者作为研究对象，35例患者使用布地奈德进行治疗，作为对照组，35例患者使用多索茶碱联合布地奈德进行治疗，作为观察组，比较两组患者治疗效果、治疗前后肺部通气功能和不良反应发生率。结果观察组治疗有效率为94.29%，对照组为80.00%，P0.05；观察组治疗后肺部通气功能明显高于对照组，P0.05；两组患者不良反应发生率组间差异无统计学意义，P0.05。结论多索茶碱联合布地奈德可有效提高支气管哮喘治疗效果，对于改善患者肺部通气功能效果显著，且临床应用不良反应较少，安全性良好，值得推广应用。

【关键词】支气管哮喘；布地奈德；多索茶碱

Efficacyandsafetyofcombinedapplicationofdoxotheophyllineandbudesonideinthetreatmentofbronchialasthma

LiuSu

TheFirstAffiliatedHospitalofUSTC,pisionofLifeSciencesandMedicine,UniversityofScienceandTechnologyofChina,Hefei,Anhui,230001,P.R.China

[Abstract]objectivetoanalyzetheefficacyandsafetyofthecombinedapplicationofdoxofophyllineandbudesonideinthetreatmentofbronchialasthma.MethodcollectedinJune2017toMay2019,ourhospital70casesofbronchialasthmapatientsastheresearchobject,35patientswithbudesonidetreatment,asthecontrolgroup,35casesofpatientswithjointbudesonidedoxofyllinetreatment,astheobservationgroup,comparedtwogroupsofpatientsbeforeandafterthetreatmenteffects,pulmonaryventilationfunctionandtheincidenceofadversereactions.Resultstheeffectiveratewas94.29%intheobservationgroupand80.00%inthecontrolgroup,P0.05.Pulmonaryventilationfunctionintheobservationgroupwassignificantlyhigherthanthatinthecontrolgroup(P0.05).Therewasnostatisticallysignificantdifferenceintheincidenceofadversereactionsbetweenthetwogroups(P0.05).Conclusionthecombinationofdoxotheophyllineandbudesonidecaneffectivelyimprovethetherapeuticeffectofbronchialasthma.Ithasasignificanteffectonimprovingthepulmonaryventilationfunctionofpatients,withfewadversereactionsinclinicalapplicationandgoodsafety.Therefore,itisworthyofpromotionandapplication.

【Keywords】bronchialasthma;Bou