苯并(a)芘诱导的肺细胞癌变过程中时间异质性的拉曼光谱分析.pdfVIP

ResearchPapers研究报告

生物化学与生物物理进展

ProgressinBiochemistryandBiophysics

2024，51（6）：1458~1470

RamanSpectroscopyAnalysisofTheTemporal

HeterogeneityinLungCellCarcinogenesisInduced

byBenzo(a)pyrene*

1)**,***1)**1)1)

ZHOUHai-Tao,YAOWei,CUICao-Zhe,ZHOUXiao-Tong,

3)2)2)1)***1)***

LIANGXi-Long,QINCheng-Bing,XIAOLian-Tuan,WUZhi-Fang,LISi-Jin

(1)CollaborativeInnovationCenterofMolecularImagingPrecisionMedical,DepartmentofNuclearMedicine,TheFirstHospitalofShanxiMedical

University,ShanxiMedicalUniversity,Taiyuan030001,China;

2)CollaborativeInnovationCenterofExtremeOptics,ShanxiUniversity,InstituteofLaserSpectroscopy,StateKeyLaboratoryofQuantumOpticsand

QuantumOpticsDevices,Taiyuan030006,China;

3)CentralLaboratory,TaiyuanCentralHospitalofShanxiMedicalUniversity,Taiyuan030001,China)

AbstractObjectiveTemporalheterogeneityinlungcancerpresentsasfluctuationsinthebiologicalcharacteristics,genomic

mutations,proliferationrates,andchemotherapeuticresponsesoftumorcellsovertime,posingasignificantbarriertoeffective

treatment.Thecomplexityofthistemporalvariance,coupledwiththespatialdiversityoflungcancer,p