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WelcomeEachofYoutoMyMolecularBiologyClass1
MolecularBiologyoftheGene,5/E---Watsonetal.(2004)PartI:ChemistryandGeneticsPartII:MaintenanceoftheGenomePartIII:ExpressionoftheGenomePartIV:RegulationPartV:Methods2005-5-102
PartIVRegulationCh16:RegulationinprokaryotesCh17:RegulationineukaryotesCh18:RegulationduringdevelopmentCh19:Comparativegenomicsandevolutionofanimaldiversity3
Housekeepinggenes:expressedconstitutively,essentialforbasicprocessesinvolvingincellreplicationandgrowth.Induciblegenes:expressedonlywhentheyareactivatedbyinducersorcellularfactors.Expressionofmanygenesincellsareregulated4
Chapter16RegulationprinciplesandHowgenesareregulatedinbacteriaChapter17BasicmechanismofgeneexpressionineukaryotesChapter18HowgenesareregulatedtobestowcelltypespecificityinagroupofgeneticallyidenticalcellsChapter19Howdifferentanimalsdiverseingenomes,whyhumanissospecial?5
SurfingthecontentsofPartIV6
Someofthepeopleswhosignificantlycontributetotheknowledgeofgeneregulation7
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Chapter16GeneRegulationinProkaryotesMolecularBiologyCourse10
TOPIC1PrinciplesofTranscriptionalRegulation[watchtheanimation]TOPIC2RegulationofTranscriptionInitiation:ExamplesfromBacteria(Lacoperon,alternativesfactors,NtrC,MerR,Galrep,araBADoperon)TOPIC3ExamplesofGeneRegulationafterTranscriptionInitiation(Trpoperon)TOPIC4TheCaseofPhageλ:LayersofRegulation11
Topic1:Principles
ofTranscriptionRegulationCHAPTER16GeneRegulationinProkaryotes5/10/200512
1-1GeneExpressionisControlledbyRegulatoryProteinsGeneexpressionisveryoftencontrolledbyExtracellularSignals,whicharecommunicatedtogenesbyregulatoryproteins:PositiveregulatorsoractivatorsINCREASEthetranscriptionNegativeregulatorsorrepressorsDECREASEorELIMIN
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