消化性溃疡采用奥美拉唑联合阿莫西林、甲硝唑治疗的临床分析1.docxVIP

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消化性溃疡采用奥美拉唑联合阿莫西林、甲硝唑治疗的临床分析

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摘要：目的：探讨奥美拉唑联合阿莫西林、甲硝唑对消化性溃疡进行治疗的效果。方法：选取2014年1月至2016年10月收治的80例消化性溃疡患者，随机分为对照组与观察组，各40例，对照组患者给予口服雷尼替丁、呋喃唑酮、甲硝唑治疗，观察组给予口服奥美拉唑联合阿莫西林、甲硝唑治疗，对两组患者的临床效果进行比较。结果：对照组患者治疗的总有效率为75.0%，观察组患者治疗的总有效率为95.0%，两组间比较，差异具有统计学意义(P0.05)；观察组患者不良反应的发生率为7.5%，低于对照组的20.0%(P0.05)；观察组患者幽门螺杆菌根除率为95.0%，高于对照组的80.0%(P0.05)。结论：奥美拉唑与阿莫西林、甲硝唑的联合使用治疗消化性溃疡，治疗有效率较高，且不良反应发生率低，在临床值得推广与应用。

关键词：消化性溃疡；奥美拉唑；甲硝唑

Clinicalanalysisofomeprazolecombinedwithamoxicillinandmetronidazoleinthetreatmentofpepticulcer

Summary:Purpose:Tostudytheeffectofomeprazolecombinedwithamoxicillinandmetronidazoleinthetreatmentofpepticulcer.Method:80patientswithpepticulcerwereselectedfromJanuary2014toOctober2016,wererandomlypidedintocontrolgroupandobservationgroup,40casesineach,thecontrolgroupweretreatedwithoralranitidine,furazolidoneandmetronidazoleinthetreatment,theobservationgroupwasgivenoralomeprazolecombinedwithamoxicillinandmetronidazoletreatment,tocomparetheclinicaleffectofthetwogroups.Results:Inthecontrolgroupthetotaleffectiveratewas75%,thepatientsintheobservationgroupthetotalefficiencyis95%,thecomparisonbetweenthetwogroups,thedifferencewasstatisticallysignificant(P0.05);patientsintheobservationgrouptheincidencerateofadversereactionwas7.5%,lowerthan20%inthecontrolgroup(P0.05);theobservationgrouppatientswithHelicobacterpylorieradicationtherateof95%,higherthan80%inthecontrolgroup(P0.05).Conclusion:Omeprazolecombinedwithamoxicillinandmetronidazoleinthetreatmentofpepticulcer,thetreatmentefficiencyishigh,andtheincidenceofadversereactionsislow,worthyofpromotionandapplicationinclinical.

Keywords:Pepticulcer;omeprazole;Metronidazole

消化性溃疡是一种常见病、多发病，主要是指胃和十二指肠的慢性溃疡疾病。消化性溃疡的主要危险因素是幽门螺杆菌感染，其形成机制与胃蛋白酶消化作用和胃酸分泌有密切联系，因此，溃疡部位常见于胃部、十二指肠或胃空肠吻合口四周。[1]

临床治疗消化性溃疡疾病多采取根