麻疹英文专题知识讲座.ppt

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麻疹英文专题知识讲座

MEASLESKeypointsDIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGYAcuterespiratoryinfectiousdiseasecausedbymeaslesvirusclinicalfeature:Fever,Cough,Runnynose,Conjunctivitis,ExanthemSpecificsign:Koplik’sSpots(akindofenanthem)2

DIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGYClassification:ARNAvirusGenus:morbillivirusFamily:paramyxoviridaeSerotype:OnlyoneLocation:Nasopharyngealsecretions,Blood,UrineofpatientsPathogen3

PathogenDIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGYmeaslesvirus4

DIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGYEpidemiologyInfectioussources:MeaslespatientsinacutestageRoutesoftransmission:DropletsprayPopulationsusceptibility:4.Epidemicfeatures:Itissusceptibletoallthepeoplewithoutinfectionorinoculation.Theageofpeakincidencewas6monthsto5yearsold.Theincidenceofbabyunder6mislower.5

DIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGYRoutesoftransmissionEpidemiologyDropletspray6

DIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGYPriortotheuseofvaccineAftertheuseofvaccineMorbidity(1/100000)Majorepidemics:500-1000Mildepidemics:4009.5in1990PeakseasonInwinterandspringInanytimeofayearEpidemiccycleMajorepidemicsappearby2-4yrintervalsEpidemiccycledisappeared,SporadiccasesincreasedAge6m-5y(98%10y)Below6mandabove5yClinicalmanifestationsTypicalcasesseveremanifestationsmorecomplicationshighmortalityAtypicalcasesmildmanifestationslesscomplicationsrarelydeathEpidemiologyEpidemicFeatures7

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DIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGY0003MeaslesVaccineInoculationinwholeChina(1968)EpidemiologyMeaslescasesofin-patientsinCHCUMS10

DIVISIONOFINFECTIOUSDISEASEANDGASTROENTEROLOGYPathophysiology11

RespiratoryepitheliumregionallymphnodesFirstviremiaMon

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