LSN3074753-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

LSN3074753

Cat.No.:HY-164492

CASNo.:1455031-68-1

分⼦式:C₂₄H₃₀FN₅O₂

分⼦量:439.53

作⽤靶点:Raf

作⽤通路:MAPK/ERKPathway

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性LSN3074753，⼀种LY3009120的类药物，是⼀种泛RAF和Raf⼆聚体抑制剂。LSN3074753对因BRAF单体

或RAF⼆聚体驱动的MAPK通路激活的肿瘤细胞表现出抑制活性，包括BRAF或KRAS突变的结直肠癌。

LSN3074753与Cetuximab(HY-P9905)联合结合，对结直肠癌PDX模型表现出加成和协同效应，特别是对于

那些有KRAS或BRAF突变的模型[1][2]。

REFERENCES

[1].YaoYM,etal.MousePDXTrialSuggestsSynergyofConcurrentInhibitionofRAFandEGFRinColorectalCancerwithBRAForKRAS

Mutations.ClinCancerRes.2017Sep15;23(18):5547-5560.

[2].SorokinA,etal.AntitumoractivityofpanRAFinhibitioninBRAFV600Emetastaticcolorectalcancer[J].2017.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE

1/1