NHTD-生命科学试剂-MCE.pdf

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NHTD

Cat.No.:HY-164513

CASNo.:2540915-70-4

分⼦式:C₂₄H₂₆N₂O₅

分⼦量:422.47

作⽤靶点:Ras;Phosphodiesterase(PDE)

作⽤通路:GPCR/GProtein;MAPK/ERKPathway;Metabolic

Enzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NHTD是⼀种KRAS-PDEδ抑制剂。NHTD通过靶向PDEδ的异戊烯基结合⼝袋，改变了KRAS的细胞定位

，从⽽抑制KRAS突变的癌细胞增殖并诱导细胞凋亡(Apoptosis)。NHTD可⽤于研究KRAS驱动的⾮⼩细胞肺

癌(NSCLC)[1]。

IC50TargetK-RAS

REFERENCES

[1].LeungEL,etal.IdentificationofanewinhibitorofKRAS-PDEδinteractiontargetingKRASmutantnonsmallcelllungcancer.IntJ

Cancer.2019Sep1;145(5):1334-1345.

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