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Insulinfordiabetes(胰岛素治疗糖尿病)
Insulinfordiabetes
2006-12-04
I.indications:
Type1diabetesmellitus,type1;
2,type2diabeticketoacidosis,hyperosmolarcoma,andlacticacidosiswithhyperglycemia;
3,severeinfection,consumptiondiseases,retinopathy,kidneydisease,neuropathy,acutemyocardialinfarctionand
cerebrovascularaccident;
4,becauseofconcomitantdiseasesneedsurgicaltreatmentoftheperioperativeperiod;
5,pregnancyandchildbirth;
Dietandoralantidiabeticdrugshavenotbeenwellcontrolledinpatientswithtype6or2diabetesmellitus;
7.Secondarydiabetescausedbytotalpancreatectomy;
8malnutritionassociateddiabetes.Two,species:
(1)classificationbysource;
1,animalinsulinextractedfromporcineandbovinepancreas,boththesameefficacy,butcomparedwithhumaninsulin,
porcineinsulinin1differentaminoacidsofbovineinsulinin3differentaminoacids,soitiseasytoproduceantibody.
2,halfadultinsulin:piginsulinthirtiethalanine,replacedwithhumaninsulinthesamethreonine,thatis,halfadultinsulin.
3.Biosynthesisofhumaninsulin:ahighlypurified
biosynthetichumaninsulinobtainedbybiotechnology,whoseaminoacidsequenceandbiologicalactivityareidenticalwiththoseofthehumanbodyitself.
(two)classificationaccordingtoefficacy,timeandlength;
1,ultrashorteffect:15minutesafterinjection,thepeakconcentrationof1--2hours.
2,shortacting(quick):30minutesafterinjection,thepeakconcentrationof2--4hours,lasting5--8hours.Includes:regular(regular)insulin(regular,insulin);zinccrystallineinsulin(crystalline,zincinsulin);semislowinsulinzincsuspension(semilente,insulin).
3,mediumeffect(lowprotaminezinc,insulin):2--4hoursafterinjectiononset,peakconcentrationof6--12hours,
lasting24--28hours.Theseinclude:slowinsulinzinc
suspension(lente,insulin);neutralprotaminezincinsulin(neutral,pr
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