氯吡格雷联合阿司匹林与单用阿司匹林治疗急性心肌梗死的临床疗效比较.pdfVIP

氯吡格雷联合阿司匹林与单用阿司匹林治疗急性心肌梗死的临床疗

效比较

【摘要】目的探讨在急性心肌梗死治疗中联用氯吡格雷和阿司匹林疗效是

否优于单用阿司匹林。方法采用随机分组分成A组(氯吡格+阿司匹林组)33例,B

组(阿司匹林组)31例,分别给予标准治疗+氯吡格雷联合阿司匹林治疗和标准治疗

+阿司匹林治疗。观察血管再通率、再闭塞率及90d时左室射血分数(LVEF)、凝

血指标、血小板聚集率。结果A组的90d时LVEF高于B组,差异有统计学意义

(P＜0.05);部分凝血酶原时间(PT)与凝血酶原活动度(PA)上变化均不显著,无统计

学意义(P＞0.05);而活化部分凝血酶时间(APTT)两组治疗后均出现升高,变化有

显著性统计学差异(P＜0.05);血小板聚集率(PAR)A组降低比B组更显著,治疗前

后比较差异有显著性意义(P＜0.05);A组再闭塞率低于B组,差异有统计学意义(P

＜0.05);A组血管开通率高于B组,差异无统计学意义(P＞0.05)。结论在治疗中

氯吡格雷联合阿司匹林近期和远期疗效优于单用阿司匹林。

【Abstract】ObjectiveExplorethetreatmentofacutemyocardialinfarction

combinedeffectofClopidogrelwithAspirinissuperiortoAspirinalone.Methods64

casesWererandomlydividedintogroupsA(clopidogrel+aspirin;n=33),B

group(aspirin;n=31),whowaregivenstandardtreatment+clopidogreltoaspirinand

standardtherapy+Aspirin.Observedrecanalizationrate,reocclusionrateandleft

ventricularejectionfraction(LVEF)of90days,coagulationparameters,platelet

aggregation(PAR).ResultsAgroupof90daysLVEFhigherthanBgroup,the

differencewasstatisticallysignificant(P＜0.05);Partialthromboplastintime(PT)and

prothrombinactivity(PA)onthechangewasnotsignificant,wasnotsignificant(P＞

0.05);Theactivatedpartialthromboplastintime(APTT)aftertreatment,therewere

increasedchangeswerestatisticallysignificantdifferences(P＜0.05);platelet

aggregationrate(PAR)AgroupdecreasedmoresignificantlythaningroupB,the

differencebeforeandaftertreatmentThereweresignificant(P＜0.05);Agroupof

re-occlusionratelowerthantheBgroup,thedifferencewasstatisticallysignificant(P

＜0.05);ApatencyrateingroupBgroup,thedifferencewasnotstatistically

significant(P＞0.05).ConclusionClopidogrelandAspirininthetreatmentofrecent

effectandlongtermeffectthanaspirinalone.

【Ke