血脂康对肥胖相关性肾病大鼠脂联素、炎症因子及尿蛋白的影响.pdfVIP

血脂康对肥胖相关性肾病大鼠脂联素、炎症因子及尿蛋白的影

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马文玲;赵湘;沈晓刚;沈维;姚炯

【摘要】Objective:ToobservetheeffectsofXuezhikangonadiponectin,

inflammatorycytokines,and24hurinaryproteininobesity-related

glomerulopathy(ORG)rats,inordertoinvestigatetherenalprotective

mechanismofXuezhikangonORGrats.Methods:ThirtymaleWistarrats

wererandomlydividedintonormalgroup,modelgroup,andXuezhikang

group,10ratsineachgroup.Normalgroupwasfedonnormaldiet,model

groupwasfedonhighfatdiet,andXuezhikanggroupwasfedwithboth

highfatdietandXuezhikang,totallyfor12weeks.Thefollowingswere

observed:serumadiponectin,interleukin-6(IL-6),tumornecrosisfactor-

α(TNF-α),24hurinaryprotein,andrenalpathologicalalterations.

Results:After12weeks,comparedwiththenormalgroup,themodelrats

serumadiponectinreduced,andIL-6and24hurinaryproteinincreased,all

withstatisticallysignificantdifferences(P0.01),butTNF-αelevated

withoutasignificantdifferencebetweenthetwogroups(P0.05);andthe

alterationofrenalpathologyinthemodelgroupwasmoretremendous

thanthatinthenormalgroup.Comparedwiththemodel

group,Xuezhikanggrouphadhigheradiponectin,lowerIL-6and24h

urinaryprotein(P0.01),andrenalpathologi-caldamagemitigated.

Conclusion:XueazhikangmayplayarenalprotectiveeffectonORGratsby

downregulatingtheexpressionofinflammatorycytokinessuchasIL-6,and

increasinganti-inflammatorycytokineslevelslikeadiponectin.%目的：观察

血脂康对肥胖相关性肾病（ORG）大鼠脂联素、炎症因子及尿蛋白的影响，探讨

血脂康对ORG大鼠肾脏保护作用机制。方法：雄性Wistar大鼠30只，随机分为

正常组、模型组和血脂康组，每组10只，分别给予普通饲料、高脂饲料、高脂饲

料+血脂康喂养12周，观察各组大鼠血清脂联素、白介素-6（IL-6）、肿瘤坏死

因子-α（TNF-α）、24h尿蛋白水平及肾脏病理变化。结果：12周后，模型组大

鼠血清脂联素水平降低，IL-6水平升高，尿蛋白排泄增加，与正常组比较，差异

有统计学意义（P均0.01），TNF-α水平虽有升高，但与正常组比较差异无统计

学意义（P跃0.05），肾脏病理损害明显。血脂康组脂联素水平升高，IL-6水平

下降，尿蛋白减少，与模型组比较，差异有统计学意义（P均0.01），肾脏病理

损害减轻。结论：血脂康可下调肥胖相关性肾病大鼠炎症因子IL-6表达，升高抗

炎因子脂联素水平，减轻炎症反应，