单细胞测序技术及其在结直肠癌中的应用.pdfVIP

天津医药2021年8月第49卷第8期

891

综述

单细胞测序技术及其在结直肠癌中的应用

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郑磊，路佳

摘要：单细胞测序是一种新兴测序技术，能够对单个细胞的基因组、转录组和表观组进行分析。基于单细胞测

序探索结直肠癌中不同的分子和临床病理特征，可以揭示结直肠癌中存在的肿瘤内异质性，同时为结直肠癌的早期

诊断、治疗和预后分析提供新的思路。对单细胞测序技术及其在结直肠癌中的应用进展进行综述，为鉴定结直肠癌

预后标志物、寻找新的治疗靶点和个性化治疗方案提供参考。

关键词：结直肠肿瘤；单细胞测序；肿瘤内异质性；治疗

中图分类号：R735.3文献标志码：ADOI：10.11958

Singlecellsequencinganditsapplicationincolorectalcancer

ZHENGLei,LUJia

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1DepartmentofColorectalOncology,2DepartmentofInfectionManagement,TianjinMedicalUniversityCancerInstituteand

Hospital,NationalClinicalCenterforCancer,KeyLaboratoryofCancerPreventionandTherapy,TianjinsClinicalResearch

CenterforCancer,Tianjin300060,China

△CorrespondingAuthorE-mail:lujiajy@163.com

Abstract:Singlecellsequencingisapowerfulnewsequencingtechnology,whichcananalyzethegenome,

transcriptomeandepigenomeinasinglecell.Basedonsingle-cellsequencing,thedifferentmolecularand

clinicopathologicalcharacteristicsoftumorheterogeneitycanbeexploredincolorectalcancer,whichprovideimportant

insightsintotheearlydiagnosis,therapyandprognosisofcolorectalcancer.Thispaperreviewedtheprogressofsingle-cell

sequencingtechnologyincolorectalcancer,soastoprovidereferencesfortheidentificationofprognosticmarkersof

colorectalcancer,thesearchfornewtherapeutictarge