七叶皂苷对三叉神经痛大鼠疼痛的改善作用.pdfVIP

七叶皂苷对三叉神经痛大鼠疼痛的改

善作用

摘要：

目的：研究七叶皂苷对三叉神经痛大鼠疼痛的改善作用。

方法：选取实验大鼠45只，按随机数字表法分为对照组（15

只）、模型组（15只）、七叶皂苷组（15只），对照组与模

型组动物均不进行干预，七叶皂苷组动物口服七叶皂苷。采用

钝性刺激和热刺激法对大鼠进行三叉神经痛疼痛反应的观察，

同时通过比较细胞因子、氧化应激指标的差异来探究七叶皂苷

治疗三叉神经痛的机制。

结果：七叶皂苷组动物的疼痛反应明显降低，且七叶皂苷组血

清中TNF-α、IL-6、MDA、SOD等指标的差异性显著高于模型

组和对照组。

结论：七叶皂苷能够显著改善三叉神经痛大鼠的疼痛反应，其

机制可能与其抑制炎症反应和氧化应激有关。

关键词：七叶皂苷；三叉神经痛；疼痛反应；细胞因子；氧化

应激。

Abstract:

Objective:Toinvestigatethealleviatingeffectof

seven-leafsaponinonpaininratswithtrigeminal

neuralgia.

Methods:Forty-fiveexperimentalratswereselected

anddividedintocontrolgroup(n=15),modelgroup

(n=15),andseven-leafsaponingroup(n=15)according

totherandomnumbertablemethod.Thecontrolgroup

andmodelgroupanimalswerenotintervened,whilethe

seven-leafsaponingroupanimalswereorally

administeredseven-leafsaponin.Thebluntstimulation

andheatstimulationmethodswereusedtoobservethe

painresponseofratswithtrigeminalneuralgia,and

thedifferencesincytokinesandoxidativestress

indicatorswerecomparedtoexplorethemechanismof

seven-leafsaponinintreatingtrigeminalneuralgia.

Results:Thepainresponseoftheseven-leafsaponin

groupanimalswassignificantlyreduced,andthe

differencesinTNF-α,IL-6,MDA,andSODindicators

intheserumoftheseven-leafsaponingroupwere

significantlyhigherthanthoseofthemodelgroupand

thecontrolgroup.

Conclusion:Seven-leafsaponincansignificantly

improvethepainresponseofratswithtrigeminal

neuralgia,anditsmechanismmayberelatedtoits

inhibitionofinflammatoryreactionsandoxidative

stress.

Keywords:Seven-leafsaponin;trigeminalneuralgia;

painresponse;cytokines;oxidativestress

Trigeminalneuralgia(TN)isadebilitatingcondition

characterizedbyseverefacialpain.Althoughseveral

therapieshavebeendevelopedforTN,thereisstilla

needformoreeffectivetreatmentoptions.Seven-leaf