放射性碘疗法(英文).pptx

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2024-11-01 发布于湖北
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放射性碘疗法(英文).pptx

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RadioiodineTherapy

I-123(123I)-------diagnosticapplicationI-124(124I)-------PETscanI-125(125I)-------diagnosticandtherapeuticapplicationI-131(131I)RadioactiveIodine……

I-125(125I)

In1942HertzandRobertsHamiltonandJ.H.LawrencehyperthyroidismIn1943Seidlinetal.thyroidcarcinomaI-131(131I)

BenignThyroidDiseasesHyperthyroidism(Graves’disease)ToxicNodularGoiterNontoxicNodularGoiter

MalignantThyroidDiseaseDifferentiateThyroidCaner(DTC)papillarythyroidcancerfollicularthyroidcancermixtureofpapillaryandfollicularthyroidcancer

Iodine-131TherapyforHyperthyroidism

SIGNSANDSYMPTOMSSkin:IncreasedSweatingandheatintolerance,onycholysis,hyperpigmentation,pruritusandthinningofthehair.Eyes:Stareandlidlag,exophtalmosifgravesdiseaseCardiac:Palpitations,exertionaldyspnea,anginal-likechestpain,tachycardia,atrialfibrillation,CHFGI:Weightloss,diarrheaNeuro-psych:Anxiety,restlessness,irritability,emotionallability,psychosis,agitation,anddepressionMetabolic/Endocrine:Hyperglycemia,lowserumtotalandhigh-densitylipoprotein(HDL)cholesterol

GRAVES’DISEASESignsandsymptomsofhyperthyroidismExopthalmos,proptosis,lidlag,orbitaledemaDiffusegoiterTSHreceptorantibodiesIncreasedRAIuptake

Graves’ophthalmopathy

DiffuseGoiter

AntithyroidDrug(ATDs)methimazolepropylthiouracilSurgeryIodine-131Therapyforhyperthyroidism

TheATDsinhibitthyroidhormonebiosynthesis.Theyareusefuleitherasaprimaryformoftherapyortolowerthyroidhormonelevelsbeforeradioactiveiodinetherapyorsurgery.Long-termATDtherapymayleadtoremissioninsomepatientswithGraves’disease.Thereisnoclear-cutstandardfordurationoftherapywithATDS,butwhenusedasprimarytherapy,theyareusuallygivenfor6monthsto2years,althoughalongerperiodofadminis