猪链球菌2型的主要毒力因子与先天性免疫逃逸机制.docxVIP

猪链球菌2型的主要毒力因子与先天性免疫逃逸机制

目录

一、内容简述................................................3

1.猪链球菌2型的危害.....................................4

2.研究意义..............................................5

二、猪链球菌2型的生物学特性.................................6

1.分类与命名............................................7

2.基本形态与结构........................................8

3.生物学功能............................................9

三、主要毒力因子...........................................10

1.血凝素...............................................11

结构与功能............................................12

与宿主细胞的相互作用..................................13

2.链球菌溶血素.........................................14

种类与特点............................................16

毒素作用机制..........................................17

3.神经氨酸酶...........................................18

结构与功能............................................20

与病毒脱壳的关系......................................21

4.其他毒力因子.........................................22

透明质酸酶............................................23

胶原蛋白酶............................................25

四、先天性免疫逃逸机制.....................................26

1.细胞表面受体变异.....................................28

遗传多样性............................................29

粘附与入侵............................................31

2.目标细胞凋亡调控.....................................32

诱导凋亡..............................................34

抑制凋亡..............................................35

3.信号通路调节.........................................36

MAPK信号通路..........................................37

NFκB信号通路..........................................38

4.逃避宿主免疫监视.....................................40

低免疫原性............................................41

免疫抑制..............................................42

五、综合防御策略...........................................44

1.疫苗研发.............................................45

2.抗生素治疗....................................