血液系统疾病与免疫.pptx

;免疫学与血液学具有天然的渊源;免疫学的许多重大进展与血液学相关;免疫介导的贫血和血小板减少症;免疫介导的贫血和血小板减少症;自身免疫性溶血性贫血

Autoimmunehemolyticanemia(AIHA);AIHA的血清学特征;免疫学特征

红细胞自身抗体的构成(n=2390);温性不完全抗体的分型(n=1825);温性不完全抗体IgG亚型的分型(n=746);AIHA溶血的两种类型;血管内溶血;临床表现－温抗体型;临床表现－冷凝集素综合征;临床表现－阵发性冷性血红蛋白尿症;AIHA的诊断;AIHA的诊断;AIHA的诊断;AIHA的免疫学分析技术;;DirectCoombs’test(DAT);间接法（IAGT）;间接法（IAGT）;AIHA的治疗;AIHA的治疗;特发性血小板减少性紫癜

Idiopathicthrombocytopenicpurpura

Immunethrombocytopenicpurpura;ITP的免疫学特征;血小板相关抗体(PAIgG);血小板表面Ig;血小板表面糖蛋白（GP）抗体;临床表现及实验室检查;外周血片;骨髓涂片;诊断;ITP治疗;;淋巴组织肿瘤;淋巴组织肿瘤——B细胞肿瘤;淋巴组织肿瘤——T/NK细胞肿瘤;淋巴组织肿瘤——霍奇金淋巴瘤(HL);Notethelargecellswithlarge,palenucleicontaininglargepurplenucleoliatthearrowheads.TheseareReed-SternbergcellsthatareindicativeofHodgkinsdisease.MostofthecellularcontentoffociofHodgkinsdiseaseconsistsofreactivelymphoidcells.TherearefourmainsubtypesofHodgkinsdisease:lymphocytepredominance,nodularsclerosis,mixedcellularity,andlymphocytedepletion.;Hereisalymphnodeinvolvedbylymphoma,amalignantprocesscharacterizedbytheproliferationofneoplasticlymphoidcells.Thecapsuleofthenodehasbeeninvadedandthelymphomatouscellsextendintothesurroundingadiposetissue.Notethatthefolliclesarenumerousandirregularlysized.Thisisamalignantlymphoma,smallcleavedcelltype,follicular(alsoknownas:malignantlymphoma,poorlydifferentiatedlymphocytictype,nodular).;Thispatternofmalignantlymphomaisdiffuseandnolymphoidfolliclesareidentified.Underlowpower,notethatthenormalarchitectureofthelymphnodeisobliterated.Thelymphnodeisreplacedbyaninfiltrateofsmall(mature-appearing)neoplasticlymphocytes,andtheinfiltrateextendsthroughthecapsuleofthelymphnodeandintothesurroundingfat.Thediagnosisis:malignantlymphoma,smalllymphocytictype,diffuse(alsoknownas:well-differentiatedlymphocyticlymphoma).;Themalignantlymphocyteshereareverylargewithamoderatelyabundantcytoplasm,an