芪胶升白胶囊对恶性消化道肿瘤化疗后骨髓抑制及免疫状态的影响.pdfVIP

芪胶升白胶囊对恶性消化道肿瘤化疗后骨髓抑制及免疫状态的

影响

谢菁;刘泉;吴灵芝

【摘要】目的：观察芪胶升白胶囊对恶性消化道肿瘤化疗后骨髓抑制及免疫状态

的影响。方法将140例患者随机编为两组，治疗组（化疗＋芪胶升白胶囊），72

例；对照组（单纯化疗组）68例。比较化疗前后两组患者生活质量、骨髓抑制、

血淋巴细胞百分比、血Th1和Th2类细胞因子表达水平。结果治疗组生活质量提

高率37．5％，对照组20．6％，P＜0．05；治疗组化疗后Ⅱ度以上骨髓抑制发

生率低于对照组（P＜0．05）；治疗组化疗后淋巴细胞百分含量及比值较对照组

增高明显（P＜0．05）。治疗后Th1类细胞因子表达水平状况分析，治疗组高于

本组治疗前及对照组化疗后的表达水平（P＜0．05）；治疗后，治疗组Th2类细

胞因子的表达水平明显低于治疗前及对照组化疗后（P＜0．05）。结论芪胶升白

胶囊可提高患者生活质量，降低化疗所产生的骨髓毒性，起到改善患者细胞免疫状

态的作用。%ObjectiveToobservetheeffectofQijiaoshenbaicapsuleon

bonemarrowsuppressionandimmunestateofmalignantgastrointestinal

tumorafterchemotherapy.Methods140patientswererandomlydivided

into2groups,thetreatmentgroup(chemotherapyandQijiaoshenbai

capsules),72cases;thecontrolgroup(chemotherapy),68cases.Living

qualityofpa-tients,bonemarrowsuppression,thepercentageofblood

lymphocytes,andtheexpressionlevelsofplasmaTh1、Th2typecytokines

ofthe2groupsbeforeandafterchemotherapywerecompared.Results

Theimprovementoflivingqualityofthetreatmentgroupwas37.5%,and

20.6%inthecontrolgroup,P0.05;bonemarrowsuppressionrateoverⅡ

degreeinthetreatmentgroupwaslowerthanthatofthecontrolgroup

afterchemotherapy(P-values0.05);thelymphocytepercentageandratio

ofthetreatmentgroupincreasedsignificantlycomparedwiththecontrol

groupafterchemotherapy(P0.05).TheexpressionlevelofplasmaTh1

typecytokinesinthetreatmentgroupaftertreatmentwerehigherthan

beforetreatment,andwashigherthanthatofthecontrolgroupafter

chemotherapy(P0.05);TheexpressionlevelofplasmaTh2typecytokines

inthetreatmentgroupaftertreatmentweresignificantlylowerthanbefore

treatment,andwaslowerthanthatofthecontrolgroupafter

chemotherapy(P0.05).Con-clusionQijiaoshenbaicapsulecanefficiently

enhancethelivingqualityofpatients,reducethetoxicityofbonemarrow

after