乳腺癌新辅助治疗临床思路.pptxVIP

乳腺癌新辅助治疗临床思路;;;;NSABP-B18/27

Neoadjuvantvsadjuvant“AC”;;PartⅠ:Proposalforthestandard

characterisationofthepopulationtotreat;;ShanghaiBreastCancerSurvivalStudydatas;;Subtypes;Subtypes;Allpatients

6377;OSanalysisbypCR;;PartⅡ:ProposalforUseofthefunctionalandmolecularimagineasendpoint?;PartⅡ:ProposalforUseofthefunctional

andmolecularimagineasendpoint?;;;Primaryresult-ForallcasesAUC;TheSUVdecreaserateandtumorresponse;ROCcurvesofdifferentsubtypes;PartⅡ:ProposalforUseofthefunctionalandmolecularimagineasendpoint?

Inourstudy-conclusions;;;III期、随机、对照试验，新辅助治疗

样本量：512

主要研究终点：pCR率;;PartⅢ:Evaluationoftheresponsetotreatment

2,Ki-67;PartⅢ:Evaluationoftheresponsetotreatment

3,PreoperativeEndocrinePrognosticIndex(PEPI);PartⅢ:Standardevaluationofthe

responsetothetreatment

conclusion;PartⅣ:Standarddefinitionofsurvivalendpoint?

-islacking;;Futureperspectivesandconclusions;

Thankyou!