瑞舒伐他汀联合依折麦布调脂治疗糖尿病50例临床评价 .pdfVIP

瑞舒伐他汀联合依折麦布调脂治疗糖尿病50例临床评价

李婷;何剑琴;陈连剑;冯风明;曾妍

【摘要】ObjectiveToinvestigatetheclinicaleffectandsafetyof

rosuvastatincombinedwithezetimibeintreatmentoftype2dia-betes

mellitus(T2DM)complicatinghypercholesteremia.Methods100casesof

T2DMcomplicatinghypercholesteremiawereselectedandrandomly

dividedintothetreatmentgroupandthecontrolgroup,50casesineach

group.Thetreatmentgroupwasgivenrosuvastatin10mg/dand

ezetimibe10mg/dafterdailybasictreatment,whilethecontrolgroupwas

givenonlyrosuvastatin10mg/dafterdailybasictreatment.Thechanges

offastingplasmaglucose(FPG),postprandial2hbloodglucose(2h

PG),totalcholesterol(TC),lowdensitylipoproteincholesterol(LDL-C),high

densitylipoproteincholesterol(HDL-C),alanine

aminotransferase(ALT),serumcreatinekinase(CK)after8-weektreatment

wereobservedinthetwogroups.ResultsTCandLDL-Caftertreatmentin

thetwogroupsweredecreased(P﹤0.05),moreoverthedecreaseinthe

treatmentgroupwasmoresignificantthanthatinthecontrolgroup(P﹤

0.01);HDL-C,ALTandserumCKaftertreatmentinthetreatmentgroup

weresignificantlyincreasedcomparedwiththecontrolgroup(P﹤0.

05);FPGand2hPGaftertreatmentinthetreatmentgroupwereimproved

comparedwiththecontrolgroup(P﹤0.05).ConclusionRo-suvastatin

combinedwithezetimibecaneffectivelyimprovethebloodlipidlevelin

thepatientswithT2DM,reducetheadversereactionsanddeservetobe

clinicallypromoted.%目的：观察瑞舒伐他汀联合依折麦布治疗2型糖尿病合并

高胆固醇的临床疗效及安全性。方法选择2型糖尿病合并高胆固醇患者100例，

随机分成治疗组和对照组，各50例。治疗组患者在基础治疗后给予瑞舒伐他汀

10mg/d，依折麦布10mg/d；对照组患者在基础治疗上仅给予瑞舒伐他汀10

mg/d。治疗8周后观察两组患者的空腹血糖（FPG）、餐后2h血糖（2hPG）、

总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-

C）、丙氨酸氨基转移酶（ALT）、血清肌酸激酶（CK）等的变化。结果治疗后，

两组患者的TC及LDL-C均较治疗前显著下降（P﹤0.05），且治疗组下降更明

显（P﹤0.01）；治疗组HDL-C及ALT与CK均较对照组有所升高（P﹤0.05）；

治疗组FPG及2hPG较对照组有明显改善（P﹤0.05）。结论瑞舒伐他汀联合依

折麦布更能有效改善2型糖尿病患