瑞舒伐他汀对早发冠心病患者血管内皮功能及血小板指标的影响.pdfVIP

瑞舒伐他汀对早发冠心病患者血管内皮功能及血小板指标的影

响

陈锋;李名亮;杨蓉

【摘要】目的探讨瑞舒伐他汀对早发冠心病患者血管内皮功能及血小板指标的影

响.方法选取2015年2月至2016年2月期间于攀枝花市攀钢集团总医院进行诊

治的54例早发冠心病患者为研究对象,将其根据随机数字表法分为对照组和观察组,

每组27例,对照组患者进行常规治疗,观察组在对照组基础上加用瑞舒伐他汀治疗,

然后将两组患者治疗前和治疗后1个月、3个月与6个月时的血管内皮功能相关

指标及血小板指标进行比较.结果治疗前两组患者的血管内皮功能相关指标及血小

板指标比较差异均无统计学意义(P0.05),而治疗后1个月、3个月及6个月,两组

患者的血管内皮功能相关指标及血小板指标均持续改善,治疗后6个月,观察组患者

的内皮素1(ET-1)、一氧化氮(NO)、血管性血友病因子(vWF)、可溶性血管间粘附

分子1(sVCAM-1)、血流介导的内皮舒张功能(FMD)、内皮依赖性舒张反应(EDD)

及非内皮依赖性舒张功能(EID)及平均血小板体积(MPV)、血小板分布宽度(PDW)

及膜表面α-颗粒膜蛋白-140(GMP-140)均明显优于对照组,差异均有统计学意义

(P0.05).结论瑞舒伐他汀可显著改善早发冠心病患者的血管内皮功能及血小板指

标,改善患者的循环状态.%ObjectiveToexploretheinfluenceofrosuvastatin

onvascularendothelialfunctionandplateletin-dexesinpatientswith

prematurecoronaryheartdisease.MethodsAtotalof54patientswith

prematurecoronaryheartdiseasetreatedinourhospitalfromFebruary

2015toFebruary2016wereenrolled.Theyweredividedintoobservation

groupandcontrolgroupbyarandomnumbertable(27casesineach

group).Thecontrolgroupwastreatedwithroutinetreatment,andthe

observationgroupwastreatedwithcontrol-basedtherapyand

rosuvastatin.Thevascularendothelialfunctionandplateletindexesoftwo

groupswereinvestigatedbeforethetreatmentandatthefirst,thirdand

sixthmonthafterthetreatment.ResultsNostatisticallysignificant

differencewasobservedbetweentwogroupsonthechangeofvascular

endothelialfunctionandplateletindexesbeforethetreatment(P0.05),

whiletheseindexesoftwogroupsatfirst,thirdandsixthmonthafterthe

treatmentwereallcontinuouslyimproved.Atthesixthmonthafter

treatment,vascu-larendothelialfunctionrelatedindexesendothelin-1(ET-

1),nitricoxide(NO),vonWillebrandfactor(vWF),solublevascular

adhesionmolecule1(sVCAM-1),flow-mediateddilationfmd(FMD),

endothelial-dependentvasodilation(EDD)andendothelium-independ