S-Azelastine-hydrochloride-plus-Azelastine-hydrochloride-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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(S)-Azelastinehydrochloride

Cat.No.:HY-B0462B

CASNo.:153408-27-6

Synonyms:(+)-Azelastinehydrochloride

分⼦式:C₂₂H₂₅Cl₂N₃O

分⼦量:418.36

作⽤靶点:HistamineReceptor;SARS-CoV

作⽤通路:GPCR/GProtein;Immunology/Inflammation;Neuronal

Signaling;Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(S)-Azelastinehydrochloride属于抗组胺剂，是⼀种有效的选择性组胺1(H1)拮抗剂。(S)-Azelastine

hydrochloride可⽤于过敏性⿐炎、哮喘、糖尿病⾼脂⾎症和SARS-CoV-2的研究[1][2][3][4]。

客户使⽤本产品发表的科研⽂献

•Phytomedicine.2023Apr21,154825.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].CraigLaForce.Reviewofthepharmacology,clinicalefficacy,andsafetyofazelastinehydrochloridel.ExpertRevClinImmunol.2005

Jul;1(2):191-201.

[2].MohamedMElseweidy,etal.Azelastineapotentantihistamineagent,ashypolipidemicandmodulatorforaorticcalcificationindiabetic

hyperlipidemicratsmodel.ArchPhysiolBiochem.2020Jul2;1-8.

[3].CarlosD.Zappia,etal.Azelastinepotentiatesantiasthmaticdexamethasoneeffectonamurineasthmamodel.PharmacolRes

Perspect.2019Dec;7(6):e00531.

[4].LiYang,etal.IdentificationofSARS-CoV-2entryinhibitorsamongalreadyapproveddrugs.ActaPharmacolSin.2020