SC-67655-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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SC-67655

Cat.No.:HY-120794

CASNo.:182134-00-5

分⼦式:C₃₇H₆₂N₆O₉

分⼦量:734.92

Sequence:(S)-{CBA-Val-Pec}-Asp-Pro-Thr-NH-{n-Pr}

SequenceShortening:(S)-{CBA-Val-Pec}-APT-NH-{n-Pr}

作⽤靶点:Others

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性SC67655是⼀种强效且稳定的五肽MHCII类单倍型DR4（DR4Dw4或DRB10401）配体，IC50为50nM。

SC67655可⽤于⾃⾝免疫性疾病的研究。

REFERENCES

[1].SLWoulfe,etal.ApeptidomimeticthatspecificallyinhibitshumanleukocyteantigenDRB1*0401-restrictedTcellproliferation.J

PharmacolExpTher.1997May;281(2):663-9.

[2].GunnarJ.Hanson,etal.(1996).DesignofMHCclassII(DR4)ligandsusingconformationallyrestrictediminoacidsatp3andp5.,

6(16),1931-1936.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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