AFN-1252-tosylate-API-1252-tosylate-生命科学试剂-MCE.pdf

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AFN-1252tosylate

Cat.No.:HY-114622

CASNo.:1047981-31-6

Synonyms:API-1252tosylate;Debio1452tosylate

分⼦式:C₂₉H₂₉N₃O₆S

分⼦量:547.62

作⽤靶点:Bacterial;Antibiotic

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性AFN-1252tosylate是⼀种具有⼝服活性的，选择性FabI抑制剂，FabI是葡萄球菌属脂肪酸⽣物合成的必需酶

。AFN-1252tosylate对葡萄球菌表现出⾼度选择性活性。AFN-1252tosylate对⾦黄⾊葡萄球菌的不同临床分

离株的MIC90值?0.015μg/ml。AFN-1252tosylate在败⾎症⼩⿏模型中有效，可提供100%的保护，防⽌

⾦黄⾊葡萄球菌的致命腹膜感染。

客户使⽤本产品发表的科研⽂献

•NatCommun.2016Oct5;7:12944.

•SciData.2024Sep19.

•CellRep.2019Dec17;29(12):3974-3982.e4.

•Phytomedicine.2024May13:130:155732.

•PLoSPathog.2020Oct30;16(10):e1008529.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].NachumKaplan,etal.Invitroactivity(MICsandrateofkill)ofAFN-1252,anovelFabIinhibitor,inthepresenceofserumandin

combinationwithotherantibiotics.JChemother.2013Feb;25(1):18-25.

[2].NachumKaplan,etal.Modeofaction,invitroactivity,andinvivoefficacyofAFN-1252,aselectiveantistaphylococcalFabIinhibitor.

AntimicrobAgentsChemother.2012Nov;56(11):5865-74.

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