Robo 1蛋白在胃癌中的表达及临床意义 .pdfVIP

Robo1蛋白在胃癌中的表达及临床意义

张春煜;孟杰;徐大鹏;张亮

【摘要】ObjectiveTostudytheRobo1transmembraneproteinexpression

ingastriccarcinomatissueanditsrelationshipwithclinicalpathological

features.MethodsImmunohistochemicalmethodtodetectP-V54casesof

gastriccarcinomaand20casesRobo1proteinexpressionintissue

adjacenttocarcinoma,andcomparethedifferentpathological

characteristicsunderRobo1proteinexpression;WithCD34markers

capillaries,microvasculardensity(microvesseldensity,MVD),andtodiscuss

therelationshipbetweengastriccancertissuesRobo1andMVD.Results

ThepositiveexpressionrateofRobo1proteiningastriccarcinomawas

70.37%,thepositiveexpressionratewas10.00%inthetissueadjacentto

carcinoma,bothcomparison,differencewasstatisticallysignificant(χ2=

21.48,P0.05).Robo1proteinexpressionlevelandlymphnodemetastasis

andTNMstagesrelated,hasnothingtodowiththedegreeof

differentiationandtumorsize.Robo1proteinpositiveMVDingastric

cancertissuewas(24.74±2.59),significantlyhighercomparedwithtissue

adjacenttocarcinoma(18.10±1.71),withstatisticalsignificance(t=

10.629,P0.05).ConclusionHigherRobo1proteinexpressioningastric

cancer,andisassociatedwiththeclinicalpathologicalfeaturesofthe

tumor,promptRobo1proteinplaysanimportantroleintheformation

processofgastriccancer,cancerofthestomachinthemicrovascular

densityincreasedcaninfertheformationofthemicrovascularpromoted

thegrowthandinasienessoftumor.%目的：研究跨膜蛋白Robo1在胃癌组织

中的表达及其与临床病理特征的关系。方法免疫组化P-V法检测54例胃癌和20

例癌旁组织中Robo1蛋白的表达情况及Robo1蛋白在不同病理特征下的表达；

用CD34标记微血管，计算微血管密度（microvesseldensity，MVD）探讨胃癌

组织中Robo1与MVD的关系。结果Robo1蛋白在胃癌中的阳性表达率为

70.37%，在癌旁组织中的阳性表达率为10.00%，两者比较，差异有统计学意义

（χ2=21.48，P＜0.05）。Robo1蛋白的表达水平与淋巴结转移、TNM分期相

关，与肿瘤的大小、分化程度无关。Robo1蛋白在胃癌组织中MVD为