p53和Ki67在结直肠癌中的表达及其临床意义 .pdfVIP

p53和Ki67在结直肠癌中的表达及其临床意义

叶斌;王西川;雷蕾;游莉斯

【摘要】ObjectiveToinvestigatetheexpressionofproteinp53andKi67in

colorectalcarcinomaandtheirsignificance.MethodsTheexpressionof

p53andKi67in71casesofcolorectalcarcinomaof71casesand16cases

ofcolonadenocar-cinomaweredetectedbyimmunohistochemistry.

Results①Theexpressionrateofproteinp53andKi67in71casesof

colorectalcarcinomawere40.85%(29/71)and

77.46%(55/71),respectively,whichweresignificantlyhigherthanthatin

colonade-nocarcinoma.(P=0.019,P=0.000).②Incolorectal

carcinoma,theexpressionofproteinp53wassignificantlyassociatedwith

thedepthofinvasion(P=0.035),thedegreeofdifferentiation(P=0.

028),lymphnodemetastasis(P=0.013)andclinicalstaging(P=0.023).

TheexpressionofKi67wassignificantlyassociatedwiththedepthof

invasion(P=0.046)andclinicalstagingsP=0.040),butitwasnot

associatedwiththedegreeofdifferentiationandlymphnode

metastasis(P0.05).③Thepositiveexpressionofproteinp53andKi67

were40.85%and77.46%,respectively,inwhichco-positivewere26cases

andco-negativewerel3cases.Theproteinp53wascorrelatedwiththe

Ki67expression(γ=0.508,P=0.000).ConclutionTheexpressionofp53

andKi67arehigherinthecolorectalcarcinomathanthatin

adenocarcinoma.Therefore,thedetectionofproteinp53andKi67

expressioncouldbeusedasbiomarkerstopredictthedegreeof

malignancyandprognosisofcolorectalcarcinoma.%目的探讨p53蛋白、

Ki67在结直肠管状腺瘤和结直肠癌中的表达及意义.方法采用免疫组化法分别对

71例结直肠癌,16例结肠腺瘤,进行了p53蛋白和Ki67的检测.结果①结直肠癌

组织中p53蛋白、Ki67的阳性表达率分别为40.85%(29/71)、77.46%(55/71),均

显著高于腺瘤组织,差异均有统计学意义(P＝0.019,P＝0.000).②在结直肠癌组织

中p53蛋白的阳性表达与结直肠癌的临床分期、浸润深度、组织学分化程度和淋

巴结转移有关(P0.05);结直肠癌中Ki67的表达阳性率与结直肠癌的临床分期和浸

润深度有关(P0.05),与组织学分化程度和淋巴结转移无关(P0.05).③p53蛋白和

Ki67共同阳性者26例,共同阴性者13例,相关性分析显示,两者之间呈正相关

(γ=0.508,P＝0.000).结论p53蛋白和Ki67在结直肠癌中的表达明显升