GSK3βser9、p-GSK3βTyr216在宫颈癌组织中的表达及临床意义.pdfVIP

GSK3β、p-GSK3βser9、p-GSK3βTyr216在宫颈癌组织

中的表达及临床意义

陈良凤;张颖;王仲奇;邸曼;郑福利;王建

【摘要】ObjectiveToinvestigatetheexpressionsofglycogensynthase

kinase3β(GSK3β),p-GSK3βser9andp-GSK3βTyr216incervicalcarcinoma

andtheircorrelationwithclinicalpathologicalfactors.MethodsByusing

immunohistochemistry,GSK3β,p-GSK3βser9andp-GSK3βTyr216protein

expressionsweredetectedin80casesofcervicalcarcinomaadmittedin

XijingHospitalofFourthMilitaryMedicalUniversityduringJanuary2012

toDecember2014.ThecorrelationsbetweenexpressionsofGSK3β,p-

GSK3βser9andp-GSK3βTyr216andclinicopathologicalfactorswere

analyzed.ResultsThepositiveexpressionratesofGSK3β,p-GSK3βser9and

p-GSK3βTyr216incervicalcarcinomawere18.8%,68.8%and12.5%,

respectively.TheexpressionsofGSK3βandp-GSK3βTyr216inearlystage

groupweresignificantlyhigherthanthoseinadvancedstagegroup

(25.5%vs4.0%,χ2=5.193,P=0.029;76.4%vs52.0%,χ2=4.749,P=0.039),but

theexpressionrateofp-GSK3βser9wasobviouslylower(5.5%vs28.0%,χ2

=7.988,P=0.009).Thepositiveexpressionratesofp-GSK3βser9inwelland

moderatelydifferentiatedtumorswerelowerthanthoseinpoorly

differentiatedtumors(7.4%,7.9%and33.3%,χ2=7.329,P=0.031).The

expressionsofGSK3βandp-GSK3βTyr216weresignificantlylowerin

patientswithpositivelymphnodemetastasisthaninthosewithnegative

lymphnodestatus(5.9%vs28.3%,χ2=6.427,P=0.018;52.9%vs80.4%,χ2

=6.878,P=0.014),buttheexpressionofp-GSK3βser9washigherin

patientswithlymphnodemetastases(23.5%vs4.3%,χ2

=6.577,P=0.015).ConclusionTheexpressionsofGSK3β,p-GSK3βser9and

p-GSK3βTyr216incervicalcarcinomaarecorrelatedwithclinicalTNM

staging,histologicalgradesandlymphnodemetastases,whichsuggests

thatGSK3βmayplayapotentialroleincervicaltumorgenesis.%目的：检测

糖原合成酶激酶3β（GSK3β）、p-GSK3βser9和p-GSK3βTyr216表达水平在

宫颈癌