干细胞标志物SOX-2、β-catenin 表达与胃癌术后复发转移关系 .pdfVIP

干细胞标志物SOX-2、β-catenin表达与胃癌术后复发转移

关系

张燕平;罗素霞;李宁;邓文英;韩黎丽;田沛琦;许勇飞;杨姣;申威;魏辰

【摘要】Backgroundandpurpose:Therecurrenceandmetastasisofgastric

cancerseriouslyaffectsurvivalinpatients.SOXgeneasaregulatoryfactor

oftheclassicalWntpathway,mayplayanimportantroleintheprocess.

ThisstudywastoexploretheexpressionofstemcellmarkerSOX-2andβ-

cateniningastriccancerandtoanalyzetherelationshipwithrecurrence

andmetastasisafteroperation.Methods:Immunohistochemistrywasused

todetecttheexpressionofSOX-2andβ-cateninin71tumorsamplesfrom

71casesaftersurgeryforgastriccancer.ThecorrelationbetweenSOX-2

andβ-cateninexpressionandtheclinicopathologicalcharacteristicsof

gastriccanceranddisease-freesurvivalwasanalyzed.Results:TheSOX-2

proteinexpressionwasassociatedwithmetastasis,lymphnodeinifltration

ordifferentiation(P=0.011,P=0.036,P=0.034)inthe71gastriccancer,but

notwithgender,ageorTstage.β-cateninexpressionwascorrelatedwith

metastasis,lymphnodeinvasionorTstage(P=0.025,P=0.014,P=0.026),

butwasnotrelatedtodifferentiation,genderorage.Thesurvivalanalysis

showedthatSOX-2andβ-cateninexpressionwascloselyassociatedwith

prognosisofpatients,andmetastaticrateinpositiveexpressionwas

higherthanthatinnegativeexpression.Conclusion:TheexpressionofSOX-

2andβ-cateninisassociatedwiththedevelopment,recurrence,metastasis

ofgastriccancerandmaybeusedasausefulprognosticparameterto

predictoverallsurvival.%背景与目的：胃癌术后复发转移严重影响患者生存情况，

SOX基因是经典Wnt信号通路的调控因子，其在胃癌术后复发及转移过程中可能

发挥重要作用。本研究旨在探讨胃癌术后复发、远处转移患者肿瘤组织中SOX-2、

β-catenin表达情况，探讨两者在胃癌术后复发及转移的作用。方法：采用免疫组

化方法检测71例经手术切除胃癌患者的肿瘤组织中SOX-2和β-catenin蛋白表

达情况，并分析其与临床病理特征和无病生存时间(diseasefreesurvival，DFS)

的关系。结果：SOX-2在胃癌中的表达与胃癌复发转移、淋巴结浸润及分化程度

有关(P=0.011，P=0.036，P=0.034)，与患者性别、年龄及T分期无关。β-

catenin在胃癌中的表达与胃癌复发转移、淋巴结浸润及T