Ras基因及其调节异常与肿瘤发生的研究进展_张慧 .pdfVIP

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Ras基因及其调节异常与肿瘤发生的研究进展

张慧,陈洪

东南大学医学院东南大学附属中大医院消化内科,江苏南京210009

ProgressinRasgeneandrelationshipbetweenabnormalityofRasregulationandtumor

ZHANGHui,CHENHong

DepartmentofGastroenterology,ZhongdaHospital,ClinicalMedicalCollegeofSoutheastUniversity,Nanjing

210009,P.R.China

【摘要】目的:总结国内外对Ras基因及[ABSTRACT]OBJECTIVE:Tosummarizetheprogressinthe

其调节异常与肿瘤发生的相关研究进展。Rasgeneanditsregulationabnormalityandtumor.METHODS:

方法:以“Ras、RASAL1和Tumor”为关键“Ras,RASAL1geneandthetumor”weresearchedaskeywordsin

词,使用PubMed和Springer数据库检索thedatabasesofPubMedandSpringer.Atotalof106articleswere

1998-01-2009-01年相关文献,收集文献obtainedduringtheperiodofJanuary1998toJanuary2009.Inclu-

106篇。纳入标准:1)Ras基因与肿瘤的关dingcriteria:1)therelationshipbetweentheRasgeneandtumor;

系;2)Ras活性的调控机制;3)RASAL1基2)theregulationofRasactivity;3)themethylationandcouplingof

因甲基化及其偶联钙振荡;4)RASAL1与calciumoscillationsofRASAL1gene;4)RASAL1mediatingthe

转录因子PITX1的关系及结直肠肿瘤中的regulationofPITX1onRasactivity,andRASAL1expressionin

RASAL1表达。根据纳入标准,最后纳入colorectaltumor.Accordingtothecriteria,22paperswereinclud-

分析22篇。结果:RasGTP酶活化蛋白ed.RESULTS:TheRasGTPenzymeactivationprotein(Ras

(RasGAPs)具有GTP酶活性可使Ras蛋GAPs)hastheGTPenzymeactivitywhichcancausetheRaspro-

白失活;RASAL1可通过与质膜联系解码teindeactivation;RASAL1decodedcalciumoscillationsignalby

钙振荡传递的信号以及通过介导转录因子contactwiththeplasmamembraneaswellasthroughmediated

PITX1进而调节Ras活性;在结直肠肿瘤