原发性干燥综合征患者外周血B细胞瘦素表达水平及其临床意义 .pdfVIP

原发性干燥综合征患者外周血B细胞瘦素表达水平及其临床

意义

徐婷;吴敏;蔡明渊;马英淳;谢雯;张佩蓉;孙茹蓉;喻少波;徐正

【摘要】Objective:Toinvestigatetheexpressionandclinicalsignificanceof

leptin(LP)andleptinreceptor(LPR)inBcellinpatientswithprimary

Sj?gren’ssyndrome(pSS).Methods:ThemethodofFlowCytometrywas

usedtomeasuretheexpressionofLPandLPRinBcellin56patientswith

pSSandthetestresultswerecomparedwiththoseof19normalcontrols.

Thelinearcorrelationanalysiswasadoptedtoevaluatetherelationship

betweentheexpressionofLPandLPRinBcellandclinicalmanifestations.

Results:TherewasnosignificantdifferenceintheexpressionofLPin

CD19+Bcellbe-tweenpSSpatients(6.53±6.67)andthenormal

controls(4.63±2.90)%aswellasactivepSSpatients(7.17±9.19)%andin-

activepatients(5.98±3.28)(P0.05).TheexpressionofLPRinCD19+Bcell

wassignificantlyhigherinpSSpatients(25.21±18.33)%thaninthenormal

controls(17.93±9.32)%,(P=0.029),andsignificantlyhigherinactivepSS

patients(30.65±20.45)%thaninactivepatients(20.49±15.08)%(P=0.037).

TheexpressionofLPwaspositivelycorrelatedwiththeexpressionofLPR

inCD19+Bcell(r=0.332,P=0.004).TheexpressionofLPinCD19+Bcell

wasnegativelycorrelatedwiththeserumlevelofLowdensity

lipoprotein(r=-0.276,P=0.030)andcreatinine(r=-0.256,P=0.034)

significantly.Theex-pressionofLPRinCD19+Bcellwasnegatively

correlatedwithweight(r=-0.294,P=0.010)andbodymassindex(BMI)(r=-

0.296,P=0.010)significantly.TheexpressionofLPRinCD19+Bcellinthe

groupwithoralulcerwassignificantlyhigherthanthosewithoutoralulcer

(P0.01).Conclusion:ThereisLPRinCD19+BcellimbalanceinpSS

patients,andthisiscorrelatedwithpSSactivityindexes.Theexpressionof

LPispositivelycorrelatedwiththeexpressionofLPRinCD19+Bcell.LPand

LPRcanregulatefatmetabolismandbodyweight,whichmaybeinvolved

inrenalin