路氏润燥汤治疗原发性干燥综合征口干疗效对照研究 .pdfVIP

路氏润燥汤治疗原发性干燥综合征口干疗效对照研究

聂彦阁;王福斌;王晶

【摘要】Objective:ToevaluatetheclinicalefficacyofLushiRunzao

DecoctioninthetreatmentofxerostomiainprimarySjogrensyndrome.

Methods:Atotalof84patientswithprimarydryingsyndromeofdual

deficiencyofqiandyinandbloodstasissyndromefromJanuary2015to

January2016inourhospitalwereselectedasresearchobjects.Theywere

randomlydividedintothetreatmentgroup(42cases)andcontrolgroup

(42cases)bycomputermethod.TreatmentgroupweregivenoralLushi

RunzaoDe-coction,thecontrolgroupwasgivenoralsulfate

hydroxychloroquinetreatment.Theclinicalefficacyofthetwogroups,

serologicalindexesandandadversereactionbeforeandafterthe

treatmentwerecompared.Results:Aftertreatment,thetheeffectiverateof

thetreatmentgroupandthecontrolgroupwere97.62%and85.71%

respectively,thedifferencewasstatisticallysignificant(P0.05).After

treatment,salivaryflowrate,drymouthsymptoms,VASscoreandChinese

medicinesyndromesofthepatientsinbothgroupimprovedsignificantly,

butthetreatmentgrouphadsignificantlybetterresults(P0.05).After

treatment,theserumRF,ESRandCRPofpatientsdroppedsignificantlyin

bothgroupsafterthetreatment,butthetreatmentgroupdecreasedmore

ob-viously(P0.05).Conclusion:LushiRunzaoDecoctionhasgoodefficacy

inthetreatmentofxerostomiainprimarySjogrensyn-drome,withgood

improvementinVASscore,salivaryflowrateandChinesemedicine

syndromes,aswellasserumRF,ESRandCRPlevels,whichisworthyof

clinicalapplication.%目的：：探讨路氏润燥汤治疗原发性干燥综合征口干的临床

疗效。方法：以2015年1月至2016年1月在我院接受治疗的84例原发性干燥

综合征气阴两虚、瘀血阻络证患者为研究对象,采用计算机法随机分为治疗组(42例)

和对照组(42例)。治疗组给予口服路氏润燥汤治疗,对照组给予口服硫酸羟化氯喹

治疗,对2组的临床疗效、治疗前后血清学指标及治疗过程中不良反应发生情况等

进行比较。结果：治疗后,治疗组于对照组治疗的有效率分别为97．62%和

85．71%,差别比较具有统计学意义(P0．05)。治疗后,2组患者唾液流率、口干

症状VAS评分和中医症候积分均较同组治疗前明显改善,但治疗组改善的更显著

(P0．05)。治疗后,2组患者血清RF、ESR及CRP均较同