内科学系统性红斑狼疮於强.ppt

SystemicLupus

ErythematosusZhongshanHospital於强

achronic,relapsing,inflammatory,

andoftenfebrilemultisystemicdisease

ofconnectivetissue,characterized

principallybyinvolvementoftheskin.WhatisLupus01anautoimmunediseaseJoints,kidneysandserosalmembranes.02

一.Typesoflupus▲Discoid▲Systemic▲Drug-induced

二.Characteristicofdisease:Atuoimmune1Targettissuedamage:2connectiontissue(shin、Joint、3muscles)4Predominantlypopulation：5women6duringtheirreproductiveyear90%7morbidity：70per100，0008

三.Pathogenicfactor▲Susceptibilitygene：HLA-DR/DQ▲EnvironmentalFactors：a.ultravioletlightb.foodhighcaloris,saturatedfat,sproutc.drugsisoniazid,methyldopaD-penicillaminechlorpromazine▲Sexhormone▲Infectionsagents

03appeartoinvolvemultiple02immunologicabnormalitiesthat01withacomplexsetof04mechanismsofdysregulation四.pathogenesis

Susceptibilitygene01EnvironmentalFactorsSexhormone02HelperTcellactivity03HyperactivatedBcell04Immunecomplex05Selfantibody+selfantigens06Multiplesysteminvolvementvasculitis

五.Pathology

1.vasculitis

2.lupusnephritis

a.minimalchange

b.mesangialproliferative

c.focalsegmentallesions

d.diffuse

e.membranous

f.sclerosing

ClinicalmenifestationsofSLE----Multiplesysteminvolvement

1Nonspecificsymptom2fever3lossofweight4debilitity

2.Skinandmucosa

●skinsymptomsin80%ofpatients

●specificfe