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***ReductionsinHbA1cindicateanimprovementinbloodglucosecontrol,whichisassociatedwithareducedriskofcomplications.****中国的糖尿病患者人群巨大。到2008年,估计实际上有超过4千万的糖尿病患者。而A1C达标率相当的低,糖尿病治疗任重道远。*8***GuidelinesfromdiabetesorganizationsrecommendtargetsforHbA1cof6.0–7.0%inindividualswithtype2diabetes:AmericanDiabetesAssociation(ADA):7%1AmericanAssociationofClinicalEndocrinologists(AACE):6.5%2InternationalDiabetesFederation(IDF)EuropeanDiabetesPolicyGroup:?6.5%3CanadianDiabetesAssociation(CDA):?7%4UKNationalInstituteforClinicalExcellence(NICE):6.5–7.5%5LatinAmericanDiabetesAssociation(ALAD):6–7%6Asian-PacificType2DiabetesPolicyGroup(APPG):6.5%7Australia:?7%.8Inaddition,atargetofHbA1c6%(normalrange)isrecommendedinindividualsinwhomitcanbeachievedsafely.1,4However,lessintensiveglycemicgoalsmaybeindicatedinsomeindividuals,e.g.theelderlyandthosewhoarepronetohypoglycemia.
1AmericanDiabetesAssociation.DiabetesCare2004;27(Suppl.1):S15–S34.
2AmericanAssociationofClinicalEndocrinologists.EndocrPract2002;8(Suppl.1):40–82.
3EuropeanDiabetesPolicyGroup.DiabetMed1999;16:716–730.
4CanadianDiabetesAssociation.CanJDiabetes2003;27(Suppl.2):S1–S152.
5NationalInstituteforClinicalExcellence.2002.Availableat:.uk.
6ALAD.RevAsocLatDiab2000;Suppl.1.
7Asian-PacificPolicyGroup.PracticalTargetsandTreatments(3rdEdition).
8NSWHealthDepartment.1996.**Thisslidevisualizestheentiretreatmentalgorithmfortype2diabetesproposedbytheADAandEASDconsensusgroup.Theflowdiagramclearlyshowsthatinsulinisthemosteffectiveagenttoaddtoapatient’streatmentregimenwhenlifestyleinterventionandmetformintherapycannotmaintaintargetglycemialevels.Alsodemonstratedistheneedforbasalinsulintherapyandeventuallyprandialinsulintherapynomatterwhichtreatmentpathisfollowed.Al
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