《医学微生物学》医学真菌学 第36、37章-英文教学课件（非AI生成）.ppt

Directfluorescentantibodycanbeappliedtohistologicalsectionsandculturesamples*IVPreventionandtreatment*PreventionandtreatmentNospecificprevention.AvoidcontactdirectlyAntifungalchemicalagents.eg.AmphotericinB、Nystatin、Fluconazole、caspofunginAmphotericinB,Azole,Echinocandin,nikkomysin*IVPathogenicFungi*TheclassificationofmycosesSiteofinfection?Superficial?Cutaneous?Subcutaneous?Deep(systemic)Routeofinfection?Exogenous–Airborne–Cutaneous?Endogenous–Colonizationfromnormalflora–ReactivationofpreviousinfectionVirulence?Primarypathogen(innormalhost)?Opportunisticpathogen(inimmunocompromisedhost)??Superficialmycoses??Cutaneousmycoses??Subcutaneousmycoses??Systemic(deep)mycoses??Opportunisticmycosesclinicalclassification*CutaneousmycosesDermatophytesfungithatinfectthesuperficialkeratinizedtissue(skin,hair,andnail).Thetineaorringwormofskin,hairandnail3genura:TrichophytonEpidermophytonMicrosporum*Pathogenicity-tineaofskin

TrichophytonEpidermophytonMicrosporumTineacorporisTineamanusTineacrurisTineapedis*Tineaofnail-tineaunguiumTrichophytonEpidermophytonMicrosporumtineabarbaeofbeard*Tineaofhair-tineacapitisTrichophytonEpidermophytonMicrosporum*Diagnosis---relyondemonstrationoffungalhyphaebymicroscopyofskin,hairandnailisolationinculturePreventionandtreatmentPreventionTreatwithtopicalagents,oraltherapy*Lactophenolcottonblueshowingmulticelledmacroconidiaandteardrop-andpeg-shapedmicroconidiaTrichophytonMicrosporumRough-walledmacroconidiasmooth-walledmacroconidiaEpidermophytonTrichophytoncigar-shapedmacroconidiaandgrapelikeclustersofmicroconidia*OpportunisticmycosesMainlycausedby5genusesSaccharomyces(假丝酵母菌属）Cryptococcus（隐球菌属）Pneumocystis（肺孢子菌属）Aspergillus（曲霉菌