心血管系统疾病课件.ppt

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Chapter8:DISEASESOFCARDIOVASCULARSYSTEM

ContentsSection1AtherosclerosisSection2CoronaryASandCHDSection3HypertensionSection4AneurysmSection5RheumatismSection6InfectiveendocarditisSection7ValvularVitiumoftheheartSection8Others

动脉粥样硬化Atherosclerosis,AS冠状动脉AS及冠心病CoronaryASCHD高血压病Hypertension动脉瘤Aneurysm风湿病Rheumatism感染性心内膜炎InfectiveEndocarditis慢性心瓣膜病Chronicvalvularvitium心肌病Cardiomyopathy心肌炎Myocarditis、心包炎Pericarditis先天性心脏病Congenitalheartdisease

ATHEROSCLEROSIS(AS)Arteriosclerosishardeningofthearteriesthickeningandlossofelasticityofarterialwallsthreeforms:AtherosclerosisM?nckebergmedialcalcificsclerosisArteriolosclerosis

ATHEROSCLEROSIS(AS)Characterizedby:Intimallesionscalledatheroma,oratheromatousorfibrofattyplaques.

Characterizedby:2.Theyprotrudeintoandobstructvascularlumina,weakentheunderlyingmedia,andmayundergoseriouscomplications.

Characterizedby:3.ASaffectselasticarteries(aorta,carotid,andiliacarteries)andlargeandmedium-sizedmusculararteries(coronaryandpoplitealarteries)

ETIOLOGYPATHOGENESISRiskFactors:hyperlipidemiahypertensioncigarettesmokingdiabetesmellitushyperhomocystinemiaothers:age,sexandgenetics

ETIOLOGYPATHOGENESIS2.Responsetoinjuryhypothesis:

EndothelialDysfunctioninAtherosclerosis.RussellRoss,NEnglJMed1999;340(2):

Fatty-StreakFormationinAtherosclerosis.

FormationofanAdvanced,ComplicatedLesionofAtherosclerosis.

UnstableFibrousPlaquesinAtherosclerosis.

TheRoleofMCP-1inAtherosclerosisMCP-1releasedbyVSMCs,ECsandmacrophagespromotestherecruitmentofmonocytesandmacrophagestothesubendothelialcelllayer.Depositionoflipidswithinthese

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