急性冠状动脉综合征血清NT-proBNP、hs-CTnT、hs—CRP和CK—MB检测及其临床意义.pdf

·272·全科医学临床与教育2013年5月第11卷第3期ClinicalEducationofGener~PracticeMay2013，Vo1．11，No．3

·临床研究·

怠陛冠状动脉综合征血清NT-proBNP、hs--cTnT、

hs—CRPgaCK—MB检测及其临床意义

潘小成

摘『要1目的探讨急性冠状动脉综合征患者血清生物标志物水平及其临床意义。方法选择急性冠脉综合征

(ACS)患者157例，其中ST段抬高型急性心肌梗死(STEMI)82~4及非ST段抬高型急性心肌梗死(NSTEMI)45例；

不稳定心绞痛(UAP)3O例、同期冠状动脉造影(CAG)阴性患者35例作为对照组。所有对象均检测NT—proBNP、hs—

cTnT、hs—CRP及CK—MB并进行分析。结果ACS综合征组血清NT—proBNP、hs—cTnT、hs—CRPT~CK—MB水平均较对

照组高，差异有统计学意义(Z分别=5．49、2．65、3．45、3．85，P均0．05)。NT—proBNP-~hs—Cr|nT和CK—MB呈正相关

性(r分别=0．65、0．22，P均0．05)；NT—proBNP诊断ACS的ROC曲线下面积为0．857。结论ACS患者血清生物标志

物升高．联合检测对早期防控ACS具有积极的临床意义。

关『键词1急性冠状动脉综合征；生物标志物；N端脑钠肽前体；超敏心肌肌钙蛋白T

SerumbiomarkerdetectionanditsclinicalsignificanceinpatientswithacutecoronarysyndromesPANXi·

aocheng．LaboratoryDepartment，AnjiPeople’SHospital，Anji313300，China

A【bstract】0bjectiveToexploreserumbiomarkerlevelsanditsclinicalsignificanceinpatientswithacutecoronary

syndromes．MethodsStudiedserumconcentrationsoffourbiomarkers(NT—proBNP，hs—cTnT，hs—CRPandCK—MB)in

157patientswithACS，inwhichtheSTsegmentelevationacutemyocardialinfarction(STEMI)were82casesandnonST

segmentelevationacutemyocardialinfarction(NSTEMI)were45cases；unstableanginapectoris(UAP)were30cases，35

patientswithnegativecoronaryarteryangiography(CAG)wereasthecontrolgroup．ResultsACSsyndromegroupselalm

NT—proBNP，hs—cTnT，hs—CRPandCK—MBlevelswerehigherthanthoseofthecontrolgroup，thedifferencesweresta—

tisticallysignificant(Z=5．49，2．65，3．45，3．85，P0．05)．NT-proBNPdisplayedastrongcorrelationwithhs—cTnTandCK—

MB(r=0．65，0．22，P0．05)；theareaunderROCcurveofplasmaNT-proBNPlevelsfordiagnosisofACSwas0．857．

ConclusionsSerumbiomarkerselevatedinpatientswithACS；combineddetectionofserumbiomarkershasapositive

clinicalsignificanceofrearlypreventionandcontrolofACS．

K【eywords】acutecoronarysyndromes；biologicalmarkers；Nterminalpro-brainnatriureticpeptide；highsensi—

tiveca