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MicheleVendruscolo
CentreforMisfoldingDiseases
ChemistryofHealthLaboratory
DepartmentofChemistry
UniversityofCambridge
TheCentreforMisfoldingDiseases
WeestablishedtheCentreforMisfoldingDiseasesin2014
withthemissionistodiscoverthemolecularoriginsofmisfoldingdiseases
andtousethisknowledgetodevelopmethodstocombatthem.
TheChemistryofHealthLaboratory
Since2018,CentreforMisfoldingDiseasesishosted
intheChemistryofHealthLaboratoryincentralCambridge.
TheChemistryofHealthLaboratorywasfundedthroughaUKprogram
topromoteearly-stagepartnershipsbetweenacademiaandindustry.
TheChemistryofHealthIncubator
ChemistryofHealthhostsastate-of-theartincubatorspacetofacilitatethetranslation
intoclinicalapplicationsoftheresearchcarriedoutintheUniversityofCambridge.
ThisChemistryofHealthIncubatorhostsspin-outcompaniesthatfocus
onthedevelopmentofanalytical,diagnosticandtherapeutictools.
Alzheimer鈥檚disease
Socialcostsofdementia
Theannualcostofdementiaislargerthanthatof
cancerandheartdiseasecombined(UKdata).
Source:Alzheimer鈥檚ResearchTrust
Fundingdementiaresearch
Dementiareceivestentimeslessresearchfundingthancancer,
despitecausingasimilarnumberofdeaths
andcostingtwiceasmuchtoourhealthcaresystem.
Source:Alzheimer鈥檚ResearchTrust
Thisapproachtodrugdiscoveryisrepeatable
acrossthe55+proteinmisfoldingdiseases
Wearecurrentlyfocusingontheextensionofthisstrategy
toParkinson鈥檚disease,ALSandtype2diabetes
Alzheimer鈥檚diseaseisassociatedwithproteinaggregation
ThemolecularhallmarksofAlzheimer鈥檚diseaseareaberrantpro
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