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;;一、中国药理学报（ActaPharmacologicaSinica)
Sample1
ActaPharmacologicaSinica2007February;28(2):238-245
Effectofgenisteinonmouseblastocystdevelopmentinvitro
;;;Conclusions:11)Ourresultscollectivelyindicatethatgenisteintreatmentofmouseblastocystsinducesapoptosis,decreasescellnumbers,retardsearlypostimplantationblastocystdevelopment,andincreasesearly-stageblastocystdeathinvitro,whiledietarygenisteinappearstonegativelyaffectmouseembryonicdevelopmentinvivobyinducingcellapoptosisandinhibitingcellproliferation.12)Thesenovelfindingsprovideimportantnewinsightsintotheeffectofgenisteinonmouseblastocysts.;Sample2
Effectofnicotinamideonnewlydiagnosedtype1diabeticchildren
Abstract
Aim:Todeterminewhetheralowdoseofnicotinamide(NA)therapyforpediatricpatientswithtype1diabetes,initiatedwithinthefirst24hofdiagnosis,prolongsthehoneymoonperiodandlowerstheirinsulinrequirements.;Methods:Allchildren(n=66)withnewlydiagnosedtype1diabetesadmittedtoSalmaniyaMedicalComplexbetween1998and2000,receivedNA1-2mg/kgperday,inadditiontoscinsulinbid.Thepatientswerefollowedfor24months(NAgroup).Findingsinthisgroupwerecomparedwithrecordsfromasimilarlydiagnosedcontrolgroup(n=37),whowereadmittedtothesamehospitalbetween1995and1997anddidnotreceiveNAtreatment.Theinsulindoseperkgbodyweightrequiredatbaselineandat3-monthlyintervalsupto2yearsafterdiagnosiswasdetermined.;Results:Atbaseline,thetwogroupsdidnotdifferwithrespecttoage,ethnicbackground,weight,insulindoseperkgbodyweightorglucoselevelsonadmission.However,NAgrouphadlowerinsulinrequirementsthancontrolgroupateach3-monthintervalupto2yearsafterdiagnosis.Conclusion:OurstudyresultssuggestthatevenlowdosesoforalNAgiventochildrenwithnewlydiagnosedtype1diabetesmayredu
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