滤泡淋巴瘤的治疗策略.ppt

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2024-12-27 发布于广东
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滤泡淋巴瘤的治疗策略.ppt

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***********CHOP,cyclophosphamide,doxorubicin,vincristine,prednisone;CR,completeresponse;CRu,unconfirmedcompleteresponse;CVP,cyclophosphamide,vincristine,prednisone;FCM,fludarabine,cyclophosphamide,mitoxantrone;FL,follicularlymphoma;PR,partialresponse;R,rituximab.?ThisquestionwasaddressedinthePRIMAtrialwithdatapresentedatthe2010AmericanSocietyofClinicalOncologyannualmeeting.Patientswithfollicularlymphoma,includingthosewithfollicularlymphomagrade3,weretreatedwitheitherR-CHOP,R-CVP,orrituximabwithafludarabine-containingregimenbasedonthephysician’schoice.Patientswhorespondedwererandomizedtoeitherobservationortorituximabmaintenancewith1doseevery8weeksfor2years.?Formoreinformation,goonlineto:/Oncology/Conference%20Coverage/Clin%20Onc%20June%202010/Tracks/Hematologic%20Malignancies/Capsules/8004.aspxEvolvingStandardsofCareinNon-HodgkinsLymphoma***CR,completeresponse;FL,follicularlymphoma;Maint,maintenance;Ph,phase;PR,partialresponse;QoL,qualityoflife;TTF,timetotreatmentfailure.RichardI.Fisher,MD:TheRESORTE4402trialisanimportantstudyaddressingtheroleofrituximabmaintenancetherapyinlowtumorburdenfollicularlymphoma.Inthistrial,patientswhoachievedcompleteorpartialremissionto4weeksoffrontlinerituximabwererandomizedtomaintenancerituximabevery3monthsuntiltreatmentfailureorretreatmentwithrituximabonlyatthetimeoftreatmentfailure.Theprimaryendpointwastimetotreatmentfailure,andthemedianfollow-upwas3.8years.Asbackground,ithasbeenknownforalongtimethatpatientswithlowtumorburdenfollicularlymphomadowellwithshort-termrituximabmonotherapy.Additionaldatahavesuggestedthattheyexperienceevenmorefavorableoutcomeswhengivenmaintenancerituximabaftertheinitialdosingperiod.[1]However,asmall,underpoweredrandomizedstudyfromHa