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AtherothrombosisPathophysiology
WhatIsAtherothrombosis?Theformationofathrombusonanexisting
atheroscleroticplaqueAtherothrombosisisanewtermrecognizingthatatherosclerosis(plaquedevelopment)andacutethrombosisareintegrallyrelatedtothepresentationofvasculareventsAgeneralizedprogressivediseaseoflarge-and
mid-sizearteriesthataffectsmultiplevascularbeds,includingcerebral,coronary,andperipheralarteriesTheunderlyingdiseaseleadingtomyocardialinfarction(MI),peripheralarterialdisease(PAD),ischemiaandmanyformsofstrokeMI,myocardialinfarction;PAD,peripheralarterydisease.
FusterV,etal.VascMed.1998;3:231-239.RauchU,etal.AnnInternMed.2001;134:122-238.
Atherothrombosis*isthe
LeadingCauseofDeathWorldwide1* Atherothrombosisdefinedasischemicheartdiseaseandcerebrovasculardisease.1 TheWorldHealthReport2001.Geneva.WHO.2001.22.319.312.69.796.3051015202530Atherothrombosis*InfectiousDiseaseCancerInjuriesPulmonaryDiseaseAIDSCausesofMortality(%)
AtherothrombosisSignificantly
ShortensLifeAnalysisofdatafromtheFraminghamHeartStudy.PeetersA,etal.EurHeartJ.2002;23:458-466.Atherothrombosisreduceslifeexpectancybyaround
8-12yearsinpatientsagedover60years1AverageRemainingLifeExpectancyatAge60(Men)048121620HealthyYearsHistoryofAMI-9.2yearsHistoryofCardiovascularDisease-7.4yearsHistoryofStroke-12years
3.2MillionHospitalAdmissionsCoronaryAtherosclerosisAcuteMyocardialInfarction
1,153,000Admissions829,000
AdmissionsHospitalizationsintheUS
DuetoVascularDiseaseCerebrovascularDisease961,000AdmissionsVascularDiseaseOtherIschemic
HeartDisease280,000AdmissionsPopovicJR,HallMJ.AdvanceData.2001;319:1-20.
PreventableDeathsApproximately57,000deathscouldbeavoidedeachyear
intheUSifpatientsweregivenappropriatecare.NationalCommitteeforQualityAssurance.Washington,DC2003.700Cervical-cancerscreeningPrenatalcare?-
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