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心源性猝死的预防和治疗.ppt

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SuddenCardiacDeath:PreventionandTreatmentLexinWang,M.D.,Ph.D.ProfessorofClinicalPharmacologyHead,CardiovascularResearch

IncidenceofSCDSCD(causedbysuddencardiacarrest)isthemostcommoncauseofdeathinWesternsocietiesIncidence:300,000to400,000eachyear(U.S.)only2%–15%reachthehospitalHalfoftheseearlysurvivorsdiebeforedischarge

RiskFactorsofSCDLeftventricularfailureCHD,cardiomyopathySuddencardiacdeathsyndromesLongQTsyndromesBrugadasyndromePolymorphiccatecholaminergicVTIsolatedventricularfibrillation

CADhasbecomeamaincauseofSCD

80%

CAD15%cardiomyopathy5%other*HuikuriHV.NEnglJMed.2001;345:1473-1482.MyerburgRJ.HeartDisease,ATextbookofCardiovascularMedicine.6thed.W.B.Saunders,Co.2001.*ion-channelabnormalities,valvularorcongenitalheartdisease,othercauses

BayésdeLunaA.AmHeartJ.1989;117:151-159.Bradycardia17%MonomorphicVT

62%PrimaryVF8%TdP13%PrevalenceofarrhythmiaatSCD

HeartFailureandSCDMorethanonemillionnewheartfailurepatientseveryyearintheUSA25%mortalityin2.5yearsinmoderatetosevereCHFAtotalof15%ofCHFpatientsdieofSCD

Gorgels,PMA.EurHeartJ.2003;24:1204-1209.LVEF%SCDVictims7.5%5.1%2.8%1.4%LVEFandSCD

CausesofdeathsinHF:mainlySCDinNYHAII-III,heartfailureinNYHAIVMERIT-HFStudyGroup.LANCET.1999;353:2001-2007.NYHAClassIIIn=103NYHAClassIIn=103NYHAClassIVn=2764%12%24%11%56%33%59%15%26%

MyocardialinfarctionandSCDAcutephase:ischemia-provokedVF;ormechanicaldysfunctions(e.g.ventricularorpapillaryrupture)Chronicphase:structuralremodellingoftheLV,leadingtore-entryorheartfailure

RiskstratificationofSCDRiskassessmentClinicaldataAetiology;familyhistory;LVEFEPSTwavealternansQTdispersionArrhythmiaduringHoltermonitoringorstresstest

IdekaT,etalJACC2006;48:2268

SensitivitySpecificityPPVNPV

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