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Acaseofverylatestentthrombosisandself-thrombolysisafterimplantationofdrugelutingstent阜外心血管病医院李崇剑杨跃进
CaseinformationMale,49y.HT(-),DM(-),Dyslipidemia(-),Smoker(-),FH(-)AMI(anteriorwall)insep.2004.EmergencyCAG:ostialLAD100%,ostialLCX60%,normalRCA.EmergencyPCI:CypherinLAD.Detailnotacquired.Drug:(Plavix75mg/d+ASA100mg/d)*1y,followedbyASA75mg/d*qod,othercardiodrugsroutinely.
CaseinformationfollowupAcutechestpain,Re-AMI(anterior)in6,Nov.2007.EmergencyCAG:cloudinstent,defectofmid-distalstent,TIMIgrade0.LCXthesameasbefore,normalRCA.CABGorPCInotperformed.Followedbydrugs:(Plavix300mg/d+ASA100mg/d+LWMH1mg/kgq12h)*12d,othercardiodrugsroutinely.
Angiograhpy(6,Nov.2007):LADandLCX
Angiograhpy(6,Nov.2007):RCA
Followup:2weekslaterCAGafter2weeks:nothrobosisinstent,LADTIMI3.LCXthesameasbefore,normalRCA.
Angiographyfollowup
DiscussionThrombosisofDESDefinitionThemechanismStrategy?今天讨论重点
DESpreventingrestenosisafterPCIStent:VesselRecoilandRemodellingDrug:IntimalProliferationDilemmaofsafety:thrombosis
ARCDefinitionofSTAcute0-24hSubacute24h-30dLate30d-1yVerylateafter1yDefinite/confirmedProbablePossibleTimecourseAngiographyandclinicalevidence
*AntiplateletTherapydiscPriorBrachyRenalfailureBifurcationsULMDiabetesUAThrombosisratesaccording
toselectedpatientcharacteristics%*PrematurediscontinuationFromA.Colombo,MD
Clinicalpredictorsofstentthrombosis0.010.11101000.010.1110100Nothieno*(0-6m)Nothieno*(6-18m)LVEF*≤30%PriorBrachytherapyRVD*FinalatmStentLengthHR=11.7;95%CI,3.47-39.24,p0.0001HR=1.01;95%CI,0.30-3.46,p=0.98HR=4.32;95%CI,1.61-11.60,p=0.004HR=9.89;95%CI,3.56-27.46,p0.0001HR=0.16;95%CI,0.03-0.82,p=0.03HR=0.41;95%
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