温阳振衰颗粒治疗慢性肾功能衰竭(阳虚证)的临床研究.pdfVIP

温阳振衰颗粒治疗慢性肾功能衰竭(阳虚证)的临床研究--第1页

温阳振衰颗粒治疗慢性肾功能衰竭(阳虚证)的临床研究

刘佑晖;李琰;蔡虎志;陈青扬;吴晓霞;陈广;马宁;陈新宇

【摘要】目的观察温阳振衰颗粒对慢性肾功能衰竭患者临床疗效及血清结缔组织

生长因子(CTGF)、转化生长因子-β1(TGF-β1)的影响.方法将患者60例按随机数

字表法分为对照组和观察组各30例,对照组给予西医常规基础治疗,观察组在此基

础上给予温阳振衰颗粒治疗,两组患者均接受8周的治疗.观察两组的疗效,比较治疗

前后肌酐清除率(Ccr)、血肌酐(Scr)、尿素氮(BUN)、血清CTGF、TGF-β1的水平.

结果观察组综合疗效、中医症候疗效总有效率明显高于对照组(P0.05);治疗后,观

察组血清CTGF、TGF-β1明显低于对照组(P0.01);观察组的Ccr、Scr、BUN亦

明显低于对照组(P0.05).结论温阳振衰颗粒可明显改善慢性肾功能衰竭患者的肾

纤维化,对慢性肾功能衰竭有较好的疗效.%Objective:Toinvestigatethe

therapeuticeffectsofWenyangZhenshuaiDecoctiononserumCTGFand

TGF-β1anditsclinicaleffectsonchronicrenalfailure.Methods:60cases

wererandomlydividedintothecontrolgroupandtheobservation

group,30casesineachgroup.Thecontrolgroupwasgivenroutine

treatmentofWesternmedicine,whiletheobservationgroupwasgiven

WenyangZhenshuaiDecoctiononthebasis.patientsweretreatedfor8

weeks.Thecurativeeffectsofthetwogroupswereobserved.Thelevelsof

Ccr,Scr,BUN,serumCTGFandTGF-β1inthetwogroupsbeforeandafter

treatmentwerecompared.Results:Theeffectiverateoftheobservation

groupwassignificantlyhigherthanthatofthecontrolgroup(P0.05).After

treatment,theserumCT-GFandTGF-β1oftheobservationgroupwere

significantlylowerthanthoseofthecontrolgroup(P0.01).Therewasno

温阳振衰颗粒治疗慢性肾功能衰竭(阳虚证)的临床研究--第1页

温阳振衰颗粒治疗慢性肾功能衰竭(阳虚证)的临床研究--第2页

differencebetweenthetwogroupsbeforetreatment,butafter

treatment,Ccr,ScrandBUNoftheobserva-tiongroupweresignificantly

lowerthanthoseinthecontrolgroup(P0.05).Conclusion:Wenyang

ZhenshuaiDecoctioncansubstantiallyimproverenalfibrosisofchronic

renalfailurepatients,soithasagoodtherapeuticef-fectinchronicrenal

f